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首页> 外文期刊>The FEBS journal >Systemic and cellular metabolism: the cause of and remedy for disease?
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Systemic and cellular metabolism: the cause of and remedy for disease?

机译：全身和细胞新陈代谢：疾病的原因和补救措施？

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The word 'metabolism' is derived from the Greek word metavoli (metabole), denoting 'change'. True to this definition, it is now appreciated that a cell or tissue cannot change its behaviour without altering its metabolism. Hence, most key cell decision-making processes are tightly coupled to metabolic change. Conversely, perturbations in metabolite abundance or flux can alter cellular (and whole-body) function profoundly, giving rise to disease. This Special Issue on Systemic and Cellular Metabolism and Disease provides an integrative perspective on the importance of metabolism for health and disease alike. Spanning several orders of scale (from metabolites, proteins, organelles, organs/tissues and whole-body physiology), these review articles cover a breadth of topics, including the importance of metabolites as signalling regulators, metabolic disease, immunity, organelle function/dysfunction, ageing and neurodegenerative disease. One of the emergent themes is that just as metabolism is the fulcrum of biology, metabolic perturbances underpin most forms of acute, chronic, infectious and non-infectious human disease; ageing and senescence could be similarly viewed. Arguably most diseases are metabolic diseases; hence, modulating metabolism may help to 'change' disease outcomes.
机译：“新陈代谢”一词来源于希腊语metavoli（代谢），表示“变化”。根据这一定义，人们现在认识到，细胞或组织在不改变其代谢的情况下无法改变其行为。因此，大多数关键的细胞决策过程与代谢变化紧密耦合。相反，代谢产物丰度或流量的扰动会深刻改变细胞（和全身）功能，从而引发疾病。这期关于系统和细胞代谢与疾病的特刊提供了代谢对健康和疾病重要性的综合视角。这些综述文章跨越了几个规模级（从代谢物、蛋白质、细胞器、器官/组织和全身生理学），涵盖了广泛的主题，包括代谢物作为信号调节器、代谢疾病、免疫、细胞器功能/功能障碍、衰老和神经退行性疾病的重要性。一个新出现的主题是，正如代谢是生物学的支点一样，代谢紊乱是大多数形式的急性、慢性、传染性和非传染性人类疾病的基础；衰老和衰老也可以被类似地看待。可以说，大多数疾病都是代谢性疾病；因此，调节新陈代谢可能有助于“改变”疾病结果。

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