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首页> 外文期刊>The Journal of Chemical Physics >Polymer brush-induced depletion interactions and clustering of membrane proteins
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Polymer brush-induced depletion interactions and clustering of membrane proteins

机译：聚合物刷诱导的脱落相互作用和膜蛋白的聚类

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摘要

We investigate the effect of mobile polymer brushes on proteins embedded in biological membranes by employing both Asakura-Oosawa type of theoretical model and coarse-grained molecular dynamics simulations. The brush polymer-induced depletion attraction between proteins changes non-monotonically with the size of brush. The depletion interaction, which is determined by the ratio of the protein size to the grafting distance between brush polymers, increases linearly with the brush size as long as the polymer brush height is shorter than the protein size. When the brush height exceeds the protein size, however, the depletion attraction among proteins is slightly reduced. We also explore the possibility of the brush polymer-induced assembly of a large protein cluster, which can be related to one of many molecular mechanisms underlying recent experimental observations of integrin nanocluster formation and signaling.
机译：我们采用Asakura-Oosawa类型的理论模型和粗颗粒分子动力学模拟，研究了可移动聚合物刷对嵌入生物膜中的蛋白质的影响。刷子聚合物诱导的蛋白质间的耗竭吸引随刷子的大小而非单调变化。由蛋白质大小与刷状聚合物之间的接枝距离之比决定的耗竭相互作用，只要聚合物刷高度小于蛋白质大小，则随刷状聚合物大小线性增加。然而，当刷子高度超过蛋白质大小时，蛋白质之间的耗竭吸引力会略微降低。我们还探讨了刷子聚合物诱导大蛋白簇组装的可能性，这可能与整合素纳米簇形成和信号传导的许多分子机制之一有关。

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