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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Early Response of SpecificIgEcan Predict Satisfaction with Sublingual Immunotherapy
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Early Response of SpecificIgEcan Predict Satisfaction with Sublingual Immunotherapy

机译：特定的早期反应预测舌下免疫疗法的满意度

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Objective To investigate predictive parameters at baseline and during the early response to sublingual immunotherapy (SLIT) for house dust mites in allergic rhinitis patients. Study Design Retrospective cohort study. Methods Patients were treated with SLIT for at least 3 years and serological tests performed at baseline and at 1-year follow-up to investigate predictive parameters. Satisfaction with SLIT, 4 nasal symptoms, and quality of life were evaluated before and after 3 years of SLIT. Sixty-one patients were enrolled and divided into two groups depending on their satisfaction after 3 years of SLIT: 43 were satisfied (70.5%) and 18 were not (29.5%). Results Immunological parameters at baseline did not differ significantly between the satisfactory and unsatisfactory groups. However, changes in bothDermatophagoides pteronyssinus(Dp)- andD. farinae(Df)-specific IgEs were significantly higher in the unsatisfactory group than in the satisfactory group during the early response to SLIT (P= .006 andP= .045, respectively). Conclusion The changes in both Dp- and Df-specific IgE levels during early response may be indicators for favorable long-term treatment outcomes with SLIT. These results suggest that clinicians could measure these immunological parameters 1 year after Dp and Df SLIT to indicate potential responders versus nonresponders. Level of Evidence 2bLaryngoscope, 2020
机译：目的探讨变应性鼻炎患者屋尘螨基线及舌下免疫治疗（SLIT）早期反应的预测参数。研究设计：回顾性队列研究。方法对患者进行至少3年的SLIT治疗，并在基线检查和1年随访时进行血清学检测，以调查预测参数。在SLIT治疗3年前后，评估患者对SLIT的满意度、4种鼻腔症状和生活质量。61名患者被纳入研究，并根据3年后的满意度分为两组：43名患者满意（70.5%），18名患者不满意（29.5%）。结果满意组和不满意组在基线检查时的免疫学参数没有显著差异。然而，翼龙舌鳎（Dp）和D的变化。在SLIT的早期反应中，不满意组的farinae（Df）特异性IgE显著高于满意组（分别为P=0.006和P=0.045）。结论Dp和Df特异性IgE水平在早期应答期间的变化可能是SLIT长期治疗效果良好的指标。这些结果表明，临床医生可以在Dp和Df SLIT术后1年测量这些免疫学参数，以指示潜在应答者与无应答者。喉镜的证据水平，2020年

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