Milk Fat Globule-Epidermal Growth Factor-Factor 8 Improves Hepatic Steatosis and Inflammation

Zhang Lei; Tian Ruifeng; Yao Xinxin; Zhang Xiao-Jing; Zhang Peng; Huang Yongping; She Zhi-Gang; Li Hongliang; Ji Yan-Xiao; Cai Jingjing

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Milk Fat Globule-Epidermal Growth Factor-Factor 8 Improves Hepatic Steatosis and Inflammation

机译：乳脂肪团簇表皮生长因子8改善肝脏脂肪变性和炎症

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Background and Aims Milk fat globule-epidermal growth factor-factor 8 (MFGE8) has been shown to be a critical extracellular molecule that mediates apoptotic signaling in the pathological process of nonalcoholic fatty liver disease (NAFLD). MFGE8 is abundantly expressed in hepatocytes, but its function in the pathogenesis of NAFLD has not been characterized.

机译：背景与目的乳脂球表皮生长因子8（MFGE8）已被证明是非酒精性脂肪肝（NAFLD）病理过程中介导凋亡信号的关键细胞外分子。MFGE8在肝细胞中大量表达，但其在NAFLD发病机制中的作用尚不明确。

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《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2021年第2期|共20页
作者
Zhang Lei; Tian Ruifeng; Yao Xinxin; Zhang Xiao-Jing; Zhang Peng; Huang Yongping; She Zhi-Gang; Li Hongliang; Ji Yan-Xiao; Cai Jingjing;
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作者单位

Wuhan Univ Dept Cardiol Renmin Hosp 238 Jiefang Rd Wuhan 430060 Peoples R China;

Wuhan Univ Dept Cardiol Renmin Hosp 238 Jiefang Rd Wuhan 430060 Peoples R China;

Wuhan Univ Inst Model Anim Wuhan Peoples R China;

Wuhan Univ Dept Cardiol Renmin Hosp 238 Jiefang Rd Wuhan 430060 Peoples R China;

Wuhan Univ Dept Cardiol Renmin Hosp 238 Jiefang Rd Wuhan 430060 Peoples R China;

Wuhan Univ Inst Model Anim Wuhan Peoples R China;

Wuhan Univ Dept Cardiol Renmin Hosp 238 Jiefang Rd Wuhan 430060 Peoples R China;

Wuhan Univ Dept Cardiol Renmin Hosp 238 Jiefang Rd Wuhan 430060 Peoples R China;

Wuhan Univ Inst Model Anim Wuhan Peoples R China;

Wuhan Univ Dept Cardiol Renmin Hosp 238 Jiefang Rd Wuhan 430060 Peoples R China;

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正文语种 eng
中图分类消化系及腹部疾病;
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1. Ping-tang Recipe （平糖方） Improves Insulin Resistance and Attenuates Hepatic Steatosis in High-Fat Diet- Induced Obese Rats [J] . 杨叔禹, 赵能江, 李学军, 中国结合医学杂志：英文版 . 2012,第004期
2. Hepatic steatosis,low-grade chronic inflammation and hormone/growth factor/adipokine imbalance [J] . Giovanni, Tarantino, Silvia, 世界胃肠病学杂志：英文版 . 2010,第038期
3. NF-κB/HDAC1/SREBP1c pathway mediates the inflammation signal in progression of hepatic steatosis [J] . Yunwei Guo, Xiaoying Zhang, Zhiyun Zhao, 药学学报：英文版 . 2020,第005期
4. NF-κB/HDAC1/SREBP1c pathway mediates the inflammation signal in progression of hepatic steatosis [J] . Yunwei Guo, Xiaoying Zhang, Zhiyun Zhao, 药学学报（英文版） . 2020,第005期
5. Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress [J] . Jie Li, Xiaotian Xu, Xiaoying Cai, Oxidative Medicine and Cellular Longevity . 2019,第47期

机译：乳脂肪球结膜生长因子因子8逆转脂多糖诱导的小胶质氧化应激
6. Evaluation of milk fat globule-epidermal growth factor-factor VIII and IL-1 beta levels in gingival crevicular fluid and saliva in periodontal disease and health [J] . Yavuz Mustafa Cihan, Pekbagriyanik Tugba, Saglam Mehmet, Odontology . 2019,第4期

机译：牙周病和健康中牙龈沟槽液和唾液中乳脂球蛋白生长因子viII和IL-1β水平的评价
7. Deficiency in milk fat globule-epidermal growth factor-factor 8 exacerbates organ injury and mortality in neonatal sepsis [J] . Hansen Laura W., Khader Adam, Yang Weng-Lang, Journal of Pediatric Surgery: Official Journal of the Surgical Section of the American Academy of Pediatric, the British Association of Paediatric Surgeons, the American Pediatric Surgical Association, and the Canadian Association of Paediatric Surgeons . 2017,第9期

机译：牛奶脂肪球蛋白 - 表皮生长因子因子8加剧了新生儿败血症的器官损伤和死亡率
8. RECENT ADVANCES IN MILK FAT DEPRESSION: 1. TIME COURSE OF MILK FAT DEPRESSION AND 2. ADIPOSE TISSUE LIPOGENESIS DURING MILK FAT DEPRESSION [C] . K. J. Harvatine, D. E. Bauman Cornell Nutrition Conference for Feed Manufacturers . 2007

机译：牛奶脂肪抑郁症的最新进展：1。乳脂抑郁症的时间进程和2.脂肪组织脂肪发生在乳脂抑郁期间
9. High Fat Diet-Mediated p38α Activation in the Liver Contributes to the Onset of Insulin Resistance and Hepatic Steatosis [D] . ?Rivers, Sydney 2020

机译：肝脏中高脂肪饮食介导的P38α活化有助于胰岛素抵抗和肝脏脂肪变性的发作
10. Milk Fat Globule-Epidermal Growth Factor-Factor 8 Reverses Lipopolysaccharide-Induced Microglial Oxidative Stress [O] . Jie Li, Xiaotian Xu, Xiaoying Cai, 2019

机译：牛奶脂肪球-表皮生长因子因子8逆转脂多糖诱导的小胶质细胞氧化应激。
11. Deficiency in milk fat globule-epidermal growth factor-factor 8 exacerbates organ injury and mortality in neonatal sepsis [O] . Laura W. Hansen, Adam Khader, Weng-Lang Yang, 2017

机译：牛奶脂肪球形缺乏表皮生长因子因子8加剧了新生儿败血症的器官损伤和死亡率
12. Low-fat Milk Consumption Among Children and Adolescents in the United States, 2007-2008. NCHS Data Brief, No. 75. [R] . Kit, B. K., Carroll, M. D., Ogden, C. L. 2011

机译：2007 - 2008年美国儿童和青少年低脂牛奶消费量。 NCHs数据简报，第75号。

Milk Fat Globule-Epidermal Growth Factor-Factor 8 Improves Hepatic Steatosis and Inflammation

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