An open-label, single-arm study evaluating the immunogenicity and safety of the hepatitis B vaccine HepB-CpG (HEPLISAV-B (R)) in adults receiving hemodialysis

Awad Ahmed M.; Ntoso Adu; Connaire Jeffrey J.; Hernandez German T.; Dhillon Kiranjit; Rich Lisa; Henderson Heather; Lynn Robert; Hyer Randall N.; Xie Fang; Erby Kimberly; Janssen Robert S.

首页> 外文期刊>Vaccine >An open-label, single-arm study evaluating the immunogenicity and safety of the hepatitis B vaccine HepB-CpG (HEPLISAV-B (R)) in adults receiving hemodialysis

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An open-label, single-arm study evaluating the immunogenicity and safety of the hepatitis B vaccine HepB-CpG (HEPLISAV-B (R)) in adults receiving hemodialysis

机译：开放标签，单臂研究评估乙型肝炎疫苗Hepb-Cpg（Heplisav-B（R））接受血液透析的成人的免疫原性和安全性

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Background: Hemodialysis patients are at increased risk of hepatitis B virus (HBV) infection and are poorly responsive to HBV vaccines. Current vaccine recommendations for hemodialysis patients utilize more than twice the amount of hepatitis B surface antigen (HBsAg) used for healthy adults and achieve lower immune responses.

机译：背景：血液透析患者感染乙型肝炎病毒（HBV）的风险增加，对HBV疫苗的反应较差。目前推荐给血液透析患者的疫苗使用量是健康成年人使用的乙型肝炎表面抗原（HBsAg）量的两倍以上，免疫反应较低。

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《Vaccine》 |2021年第25期|共7页
作者
Awad Ahmed M.; Ntoso Adu; Connaire Jeffrey J.; Hernandez German T.; Dhillon Kiranjit; Rich Lisa; Henderson Heather; Lynn Robert; Hyer Randall N.; Xie Fang; Erby Kimberly; Janssen Robert S.;
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作者单位

Clin Res Consultants 3930 Washington St Kansas City MO 64111 USA;

DaVita Franklin Dialysis 150 South Independence Mall West Philadelphia PA 19106 USA;

DaVita Clin Res 825 South 8th St Suite 300 Minneapolis MN USA;

El Paso Kidney Specialists 1310 Murchison Dr Suite 100 El Paso TX 79902 USA;

DaVita Clin Res Norfolk 962 Norfolk Sq Norfolk VA 23502 USA;

2514 South 102nd St Suite 120 Wauwatosa WI 53227 USA;

18001 East 10 Mile Rd Suite 3 Roseville MI 48066 USA;

Kidney Med Associates 34 Marconi St Suite 100 Bronx NY 10461 USA;

Dynavax Technol Corp 2100 Powell St Suite 900 Emeryville CA 94608 USA;

Dynavax Technol Corp 2100 Powell St Suite 900 Emeryville CA 94608 USA;

Dynavax Technol Corp 2100 Powell St Suite 900 Emeryville CA 94608 USA;

Dynavax Technol Corp 2100 Powell St Suite 900 Emeryville CA 94608 USA;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Hepatitis B vaccine; Toll-like receptor 9; Hemodialysis;

机译：乙肝疫苗;Toll样受体9;血液透析;

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An open-label, single-arm study evaluating the immunogenicity and safety of the hepatitis B vaccine HepB-CpG (HEPLISAV-B (R)) in adults receiving hemodialysis

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