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首页> 外文期刊>Dalton transactions: An international journal of inorganic chemistry >KLa(0.95-x)GdxF4:Eu3+ hexagonal phase nanoparticles as luminescent probes for in vitro Huh-7 cancer cell imaging dagger
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KLa(0.95-x)GdxF4:Eu3+ hexagonal phase nanoparticles as luminescent probes for in vitro Huh-7 cancer cell imaging dagger

机译：KLA（0.95-X）GDXF4：Eu3 +六方相纳米颗粒作为致烟性探针，用于体外Huh-7癌细胞成像匕首

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摘要

A facile chemical route is reported for synthesizing red-emitting photoluminescent/MRI multi-functional KLa(0.95-x)GdxF4:Eu3+ (x = 0 to 0.4) bio-compatible nanomaterials for targeted in vitro tumor imaging. Hexagonal phase pure nanoparticles show a significant and systematic change in morphology with enhanced photoluminescence due to the substitution of La3+ with Gd3+ ions. Single phase beta-KLa(0.95-x)GdxF4:Eu3+ exhibits multifunctional properties, both intense red emission and strong paramagnetism for high-contrast bioimaging applications. These silica capped magnetic/luminescent nanoparticles show long-term colloidal stability, optical transparency in water, strong red emission, and low cytotoxicity. The cellular uptake of coated nanoparticles was investigated in liver cancer cell line Huh-7. Our findings suggest that these nanoparticles can serve as highly luminescent imaging probes for in vitro applications with potential for in vivo and live cell imaging applications.
机译：报道了一种合成红色发光/MRI多功能KLa（0.95-x）GdxF4:Eu3+（x=0至0.4）生物相容纳米材料的简便化学路线，用于靶向体外肿瘤成像。由于La3+被Gd3+离子取代，六方相纯纳米颗粒的形貌发生了显著而系统的变化，并增强了光致发光。单相β-KLa（0.95-x）GdxF4:Eu3+具有多功能性质，在高对比度生物成像应用中既有强烈的红光发射，又有强顺磁性。这些二氧化硅包覆的磁性/发光纳米颗粒显示出长期的胶体稳定性、在水中的光学透明性、强红色发射和低细胞毒性。在肝癌细胞系Huh-7中研究了包覆纳米颗粒的细胞摄取。我们的研究结果表明，这些纳米颗粒可以作为体外应用的高发光成像探针，具有在体内和活细胞成像应用的潜力。

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