A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells

Graminha Angelica E.; Honorato Joao; Correa Rodrigo S.; Cominetti Marcia R.; Menezes Antonio C. S.; Batista Alzir A.

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A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells

机译：一种新的钌（II）的神经酸复合物破坏了肌动蛋白的细胞骨架并抑制三阴性乳腺肿瘤细胞的迁移，侵袭和粘附性

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This work describes the synthesis of three new ruthenium(II) complexes with gallic acid and derivatives of the general formula [Ru(L)(dppb)(bipy)]PF6, where L = gallate (GAC), benzoate (BAC), and esterified-gallate (EGA), bipy = 2,2 '-bipyridine and dppb = 1,4-bis(diphenylphosphino)butane. The complexes were characterized by elemental analysis, molar conductivity, NMR, cyclic voltammetry, UV-vis and IR spectroscopy, and two of them by X-ray crystallography. Cell viability assays show promising results, indicating higher cytotoxicity of the complexes in MDA-MB-231 cells, a triple-negative breast cancer (TNBC) cell line, compared with the hormone-dependent MCF-7 cell line. Studies in vitro with the MDA-MB-231 cell line showed that only Ru(BAC) and Ru(GAC) interacted with BSA. Besides that, the Ru(GAC) complex, which has a polyphenolic acid, interacted in an apo-Tf structure and function dependent manner and it was able to inhibit the formation of reactive oxygen species. Ru(GAC) was able to cause damage to the cellular cytoskeleton leading to inhibition of some cellular processes of TNBC cells, such as invasion, migration, and adhesion.

机译：这项工作描述了三种新的钌（II）配合物与没食子酸和通式[Ru（L）（dppb）（bipy）]PF6衍生物的合成，其中L=没食子酸盐（GAC）、苯甲酸盐（BAC）和酯化没食子酸盐（EGA）、bipy=2,2'-联吡啶和dppb=1,4-双（二苯基膦）丁烷。通过元素分析、摩尔电导率、核磁共振、循环伏安、紫外-可见光谱和红外光谱对配合物进行了表征，其中两个配合物通过X射线晶体学进行了表征。细胞活力测定显示了有希望的结果，表明与激素依赖性MCF-7细胞系相比，MDA-MB-231细胞（三阴性乳腺癌（TNBC）细胞系）中的复合物具有更高的细胞毒性。对MDA-MB-231细胞系的体外研究表明，只有Ru（BAC）和Ru（GAC）与BSA相互作用。此外，含有多酚酸的Ru（GAC）复合物以载脂蛋白-Tf结构和功能依赖的方式相互作用，能够抑制活性氧的形成。Ru（GAC）能够对细胞骨架造成损伤，从而抑制TNBC细胞的某些细胞过程，如侵袭、迁移和粘附。

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《Dalton transactions: An international journal of inorganic chemistry》 |2021年第1期|共13页
作者
Graminha Angelica E.; Honorato Joao; Correa Rodrigo S.; Cominetti Marcia R.; Menezes Antonio C. S.; Batista Alzir A.;
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Univ Fed Sao Carlos UFSCar Dept Quim Rodovia Washington Luis Km 235 CP 676 BR-13561001 Sao Carlos SP Brazil;

Univ Fed Sao Carlos UFSCar Dept Quim Rodovia Washington Luis Km 235 CP 676 BR-13561001 Sao Carlos SP Brazil;

Univ Fed Ouro Preto UFOP Dept Quim BR-35400000 Ouro Preto MG Brazil;

Univ Fed Sao Carlos UFSCar Dept Gerontol Rodovia Washington Luis Km 235 CP 676 BR-13561901 Sao Carlos SP Brazil;

Univ Estadual Goias UEG Ctr Ciencias Exatas &

Tecnol BR 153 CP 459 BR-75132903 Anapolis Go Brazil;

Univ Fed Sao Carlos UFSCar Dept Quim Rodovia Washington Luis Km 235 CP 676 BR-13561001 Sao Carlos SP Brazil;

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中图分类化学;无机化学;
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7. Arene ruthenium(II) complex, a potent inhibitor against proliferation, migration and invasion of breast cancer cells, reduces stress fibers, focal adhesions and invadopodia [J] . Wu Qiong, He Jiangtu, Mei Wenjie, Metallomics. integrated biometal science . 2014,第12期

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A novel ruthenium(II) gallic acid complex disrupts the actin cytoskeleton and inhibits migration, invasion and adhesion of triple negative breast tumor cells

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