• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cyclodextrin news >Pharmaceutical betweenPharmaceutical relevance of complex formation between cyclodextrins and phospholipids
【24h】

Pharmaceutical betweenPharmaceutical relevance of complex formation between cyclodextrins and phospholipids

机译：循环克罗斯特林和磷脂之间复合形成的药物间相关性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Editorial article of CYCLODEXTRIN NEWS April, 2002 reported on some aspects of interactions between several cell membranes and dissolved cyclodextrins focusing mainly on possible complex formation of b-cyclodextrin derivatives with cholesterol [1]. It is well known that cholesterol plays an important role in the regulation of several physical properties of the membrane of living cells, but the primary components that crucially determine the bilayer structure of cell membranes are phospholipid molecules of amphiphilic character. It is quite surprising, therefore, that relatively little attention has been paid so far to detailed study on possible interactions between cyclodextrins and the principal constituents of biological membranes. Apart from the academic interest, the natural occurrence and wide use of various phospholipids in medical applications and many other technological fields provide further supports for such investigations. Several phospholipids are used, for example, in the food industry as emulgators and also in the pharmaceutical and cosmetic industry for the preparation of artificial, but bio-compatible liposomes. These lipid vesicles are potent delivery vehicles for many drugs, since they contain a core of aqueous solution enabling the encapsulation of hydrophilic materials, while hydrophobic chemicals can be dissolved into the membrane bilayer. Due to their particular features, phospholipid liposomes have become easily accessible, simplified, models of cell membranes in biological and medical research as well.
机译：Cyclodextrin News的编辑文章2002年4月报道了几个细胞膜与溶解的环糊精之间相互作用的某些方面，主要集中于B-胞克糖糖衍生物与胆固醇的可能复合形成[1]。众所周知，胆固醇在调节活细胞膜的几种物理特性中起着重要作用，但是至关重要地确定细胞膜双层结构的主要成分是两亲性特征的磷脂分子。因此，令人惊讶的是，到目前为止，相对较少的关注对环糊精与生物膜的主要成分之间的可能相互作用进行了详细研究。除了学术兴趣外，在医疗应用中的自然发生和广泛使用各种磷脂，许多其他技术领域为此类研究提供了进一步的支持。例如，在食品工业中，使用了几种磷脂作为仿真器，也用作制药和化妆品行业，以制备人工生物兼容的脂质体。这些脂质囊泡是许多药物的有效输送车，因为它们包含能够封装亲水材料的水溶液的核心，而疏水性化学物质可以溶解在膜双层中。由于其特殊特征，磷脂脂质体在生物学和医学研究中也很容易获得，简化的细胞膜模型。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号