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Vitamin D status and hypertensive disorders in pregnancy

机译：怀孕期间维生素D的状况和高血压疾病

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Purpose: Several studies have reported increased risk of preeclampsia when 25-hyrdoxyvitamin D (25[OH]D) levels are low. The extent to which 25(OH)D may lower risk for hypertensive disorder during pregnancy remains unclear. Methods: Among women enrolled in the Project Viva prenatal cohort in Massachusetts, we examined associations of 25(OH)D levels obtained at 16.4-36.9 weeks of gestation (mean 27.9 weeks) with hypertensive disorders of pregnancy, including preeclampsia (56/1591, 3.5%) and gestational hypertension (109/1591, 6.9%). Results: We did not detect an association between plasma 25(OH)D concentration (mean 58, standard deviation 22 nmol/L) and preeclampsia. For each 25 nmol/L increase in 25(OH)D, the adjusted odds ratio for preeclampsia was 1.14 (95% confidence interval, 0.77-1.67). By contrast and contrary to hypothesis, higher 25(OH)D concentrations were associated with higher odds of gestational hypertension: adjusted odds ratio for gestational hypertension was 1.32 (95% confidence interval, 1.01-1.72) per each 25 nmol/L increment in 25(OH)D. Vitamin D intake patterns suggest that this association was not because of reverse causation. Although the elevated hypertension risk may be due to chance, randomized trials of vitamin D supplementation during pregnancy should monitor for gestational hypertension. Conclusions: These data do not support the hypothesis that higher 25(OH)D levels lower the overall risk of hypertensive disorders of pregnancy.
机译：目的：一些研究报告说，当25-羟维生素D（25 [OH] D）水平低时，子痫前期的风险增加。 25（OH）D可以降低怀孕期间高血压疾病风险的程度尚不清楚。方法：在马萨诸塞州万岁计划的产前队列研究中，我们研究了在妊娠16.4-36.9周（平均27.9周）时获得的25（OH）D水平与妊娠高血压疾病，包括先兆子痫（56/1591， 3.5％）和妊娠高血压（109 / 1591，6.9％）。结果：我们未发现血浆25（OH）D浓度（平均值58，标准差22 nmol / L）与先兆子痫之间存在关联。 25（OH）D每增加25 nmol / L，先兆子痫的调整优势比为1.14（95％置信区间0.77-1.67）。相比之下，与假设相反，较高的25（OH）D浓度与较高的妊娠高血压几率相关：妊娠高血压的调整几率比为25中每25 nmol / L增量的1.32（95％置信区间，1.01-1.72）。 （OH）D。维生素D的摄入方式表明，这种关联不是由于反向因果关系。尽管高血压的风险可能是偶然的，但怀孕期间补充维生素D的随机试验应监测妊娠高血压。结论：这些数据不支持较高的25（OH）D水平降低妊娠高血压疾病的总体风险的假设。

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