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首页> 外文期刊>Annals of epidemiology >Associations of urinary 6-sulfatoxymelatonin with demographics, body mass, sex steroids, and lifestyle factors in preschool Japanese children
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Associations of urinary 6-sulfatoxymelatonin with demographics, body mass, sex steroids, and lifestyle factors in preschool Japanese children

机译：日本学龄前儿童尿中6-硫酸酯化褪黑激素与人口统计学，体重，性类固醇和生活方式因素的关系

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Purpose: We aimed to assess the associations of sex, age, body mass, sex steroid hormones, and lifestyle factors with the levels of melatonin in young children. Methods: This study followed a cross-sectional design and was conducted two preschools in Japan. Subjects were 235 boys and 203 girls, aged 3-6 years. Information related to demographics, body mass, and lifestyle factors was obtained from parent-administered questionnaires. The levels of 6-sulfatoxymelatonin and dehydroepiandrosterone in first-void morning urine were measured by radioimmunoassay. Urinary estrone, estradiol, testosterone, and 5-androstene-3??, 17?? diol levels were measured by liquid chromatography-electrospray ionization tandem mass spectrometry. Results: The creatinine-corrected 6-sulfatoxymelatonin levels and the estimated value of 6-sulfatoxymelatonin excretion were higher in girls than in boys. After adjustments for age, the creatinine-corrected 6-sulfatoxymelatonin was negatively associated with weight and body mass index among boys and with weight and height among girls. However, the estimated value of 6-sulfatoxymelatonin excretion was not associated with any indices of body mass. No significant relationships of urinary sex steroids, light exposure at night, sleep time, sedentary lifestyles, or passive smoking with urinary 6-sulfatoxymelatonin were observed. Conclusions: Our findings suggest that melatonin levels depend on sex and body size among young healthy children. Our results should be confirmed in future researches. ? 2013 Elsevier Inc.
机译：目的：我们旨在评估性别，年龄，体重，性类固醇激素和生活方式因素与幼儿褪黑激素水平之间的关系。方法：本研究采用横断面设计，在日本的两家幼儿园进行。受试者为3至6岁的235名男孩和203名女孩。有关人口统计学，体重和生活方式因素的信息是从父母管理的问卷中获得的。通过放射免疫测定法测定初次排尿的初尿中的6-磺酰氧基褪黑激素和脱氢表雄酮的水平。尿雌酮，雌二醇，睾丸激素和5-雄甾烯-3-3、17-6通过液相色谱-电喷雾串联质谱法测定二醇水平。结果：肌酐校正的6-巯基氧基褪黑激素水平和6-巯基氧基褪黑激素排泄的估计值高于女孩。在调整了年龄之后，肌酐校正的6-硫酸根氧基褪黑激素与男孩的体重和体重指数以及女孩的体重和身高呈负相关。然而，估计的6-硫酸酯化褪黑激素排泄值与任何体重指标均不相关。没有观察到尿类固醇，夜间光照，睡眠时间，久坐的生活习惯或被动吸烟与尿中的6-硫代降氧褪黑素之间的显着相关性。结论：我们的研究结果表明，褪黑激素水平取决于年轻健康儿童的性别和体型。我们的结果应在以后的研究中得到证实。 ？ 2013爱思唯尔公司

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