...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>American journal of reproductive immunology : >Glucose/insulin metabolism and vitamin D in women with recurrent pregnancy loss
【24h】

Glucose/insulin metabolism and vitamin D in women with recurrent pregnancy loss

机译：复发妊娠丧失女性的葡萄糖/胰岛素代谢和维生素D

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Glucose/insulin metabolism has been related to recurrent pregnancy loss (RPL) through mechanisms not really clarified. Also, vitamin D deficiency seems to be associated to RPL. The purpose of our study was to evaluate the correlation between glucose/insulin metabolism parameters and vitamin D levels in women with history of RPL. Study design: Observational retrospective study on RPL women. The correlation among vitamin D levels and fasting glucose (FG), fasting insulin (FI),Homeostatic model assessment of insulin resistance (HOMA-IR) index, area under glucose curve (AUC-Glyc) and area under insulin curve (AUC-Ins), was evaluated. Results: One-hundred and twenty-seven RPL women were classified into three subgroups (0-1-2) according to the levels of FI. We found a statistically significant linear Pearson correlation between FI and HOMA-IR (r = .840; P = .001). An, inverse, but non-significant correlation both between vitamin D and FI (R = -.202, ns) and vitamin D levels and AUC-Ins (R = -.288, ns) was observed. The variables vitamin D, HOMA-IR and AUC-Ins were statistically significant in the considered subgroups (Vitamin D: ANOVA+Bonferronitest:0 vs.1;P=.001;0vs.2;P = .010;1 vs.2;P=.657;HOMA-IR: ANOVA+Bonferronitest:0 vs. 1;P= .014;0vs.2;P= .001; 1 vs.2; P = .001; AUC-Ins: ANOVA + Bonferroni test: 0 vs. 1; P = .010; 0 vs. 2; P = .206; 1 vs. 2; P = .980). Conclusions: Vitamin D might play additional roles in the pathogenesis of RPL, beyond its well known immunomodulatory role.
机译：目的：葡萄糖/胰岛素代谢与未真正澄清的机制相关的妊娠丧失（RPL）有关。同样，维生素D缺乏症似乎与RPL有关。我们研究的目的是评估患有RPL史的女性中葡萄糖/胰岛素代谢参数与维生素D水平之间的相关性。研究设计：RPL妇女的观察回顾性研究。维生素D水平与空腹葡萄糖（FG），禁食胰岛素（FI），胰岛素抵抗（HOMA-IR）指数，葡萄糖曲线（AUC-GLYC）和胰岛素曲线下的面积（AUC-GLYC）（AUC-INS（AUC-INS）（AUC-INS）（AUC-INS）的相关性（AUC-GLYC）（AUC-INS）（AUC-INS）（AUC-INS） ），评估。结果：根据FI的水平将一百二十七名RPL妇女分为三个亚组（0-1-2）。我们发现FI和HOMA-IR之间有统计学意义的线性Pearson相关性（r = .840; p = .001）。观察到维生素D和FI（r = -.202，NS）和维生素D水平和AUC -INS（r = -.288，ns）之间的AN，逆但不显着的相关性。变量维生素D，HOMA-IR和AUC-INS在所考虑的亚组中具有统计学意义（维生素D：ANOVA+BonferroneSt：0 vs.1; p = .001; 0vs.2; 0vs.2; p = .010; 1 vs.2 vs.2 vs.2 ; p = .657; homa-ir：anova + bonferronitest：0 vs. 1; p = .014; 0vs.2; p = .001; 1 vs.2; p = .001; auc-ins; auc-ins：anova + bonferroni测试：0 vs. 1; p = .010; 0 vs. 2; p = .206; 1 vs. 2; p = .980）。结论：维生素D可能在RPL的发病机理中起其他作用，超出其众所周知的免疫调节作用。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号