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首页> 外文期刊>American journal of reproductive immunology : >Maternal known drug allergy and long-term dermatological morbidity of the offspring
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Maternal known drug allergy and long-term dermatological morbidity of the offspring

机译：后代的母亲已知药物过敏和长期皮肤病发病率

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摘要

Drug allergy is associated with adverse short-term perinatal outcomes such as cae-sarian delivery and preterm delivery. The aim of the present study was to determine whether being born to a mother with known drug allergy increases the risk for long-term dermatological morbidity of the offspring. A population-based cohort study, comparing long-term dermatological morbidity of offspring to mothers with and without known drug allergy, was conducted. Dermatological morbidity was assessed up to the age of 18 years according to a predefined set of ICD-9 codes associated with hospitalization of the offspring. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term dermatological morbidity, and a Cox proportional hazards model was constructed to control of confounders. During the study period, 243,682 deliveries met the inclusion criteria, of them 4% (n = 9756) were of mothers with known drug allergy. Offspring born to mothers with known drug allergy had higher rates of long-term dermatological morbidity Likewise, the cumulative incidence of long-term dermatological morbidity was higher as compared with those without known drug allergy (Kaplan-Meier log-rank P = .021). Using a Cox proportional hazards model, controlling for confounders, being born to a mother with known drug allergy was found to be an independent risk factor for long-term dermatological morbidity of the offspring (adjusted HR 1.2, 95% Cl 1.03-1.33, P = .016). Being born to a mother with known drug allergy is independently associated with higher risk for long-term dermatological morbidity of the offspring.
机译：药物过敏与不良短期围产期结局（例如CAE-SARIAN分娩和早产交付）有关。本研究的目的是确定患有已知药物过敏的母亲出生是否会增加后代长期皮肤病学发病率的风险。进行了一项基于人群的队列研究，将后代的长期皮肤病学发病与患有或没有已知药物过敏的母亲进行比较。根据与后代住院治疗相关的一组ICD-9代码，对皮肤病学发病率进行了18岁的评估。使用Kaplan-Meier生存曲线来比较长期皮肤发病率的累积发生率，并构建了COX比例危害模型来控制混杂因素。在研究期间，有243,682次交付符合纳入标准，其中4％（n = 9756）是患有已知药物过敏的母亲。患有已知药物过敏母亲的母亲出生的后代具有更高的长期皮肤病发病率，与没有已知药物过敏的人相比，长期皮肤病学发病率的累积发生率更高（Kaplan-Meier Log-Rank P = .021） 。使用COX比例危害模型，控制混杂因素，被认为是患有已知药物过敏的母亲的出生是后代长期皮肤病学发病率的独立危险因素（调整后的HR 1.2，95％CL 1.03-1.33，P = .016）。患有已知药物过敏的母亲的出生与后代长期皮肤病发病率的较高风险独立相关。

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