The effect of sclareol on growth and cell cycle progression of human leukemic cell lines.

Dimas K; Kokkinopoulos D; Demetzos CVaos BMarselos MMalamas MTzavaras T

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The effect of sclareol on growth and cell cycle progression of human leukemic cell lines.

机译：Sclareol对人白血病细胞系的生长和细胞周期进程的影响。

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Sclareol, a labdane-type diterpene, was tested for cytotoxic effect against a panel of established human leukemic cell lines. The compound showed an IC50 lower than 20 microg/ml in most cell lines tested, while it was higher for resting peripheral blood mononuclear leukocytes (PBML). Furthermore, the compound was tested for cytostatic activity against four of the leukemic cell lines used. At a concentration of 20 microg/ml the compound showed a significant cytostatic effect as soon as 4 h after continuous incubation against two from B and two from T lineage cell lines. The morphology and the kind of death induced from sclareol in three cell lines, was also investigated. The effect of sclareol on the cell cycle progression of two cell lines, using flow cytometry, was examined. The results show that sclareol kills cell lines, through the process of apoptosis. The appearance of the apoptotic signs is time and dose dependent. From the flow cytometry experiments, a delay of the cell population on G0/1 seems to take place. This is the first report, that a labdane type diterpene kills tumor cells via a phase specific mechanism which induces apoptosis.

机译：Sclareol是一种Labdane型二萜，测试了针对一系列人类白血病细胞系的细胞毒性作用。该化合物在大多数测试的细胞系中显示出低于20微克/mL的IC50，而静息外周血单核白细胞（PBML）则较高。此外，该化合物对所使用的四种白血病细胞系进行了细胞抑制活性。在20微克/mL的浓度下，化合物在连续孵育B与B和T谱系细胞系的两个和两个连续孵育后立即显示出显着的胞抑制作用。还研究了三种细胞系中Sclareol诱导的形态和死亡。检查了Sclareol对使用流式细胞术的两种细胞系的细胞周期进程的影响。结果表明，Sclareol通过凋亡过程杀死细胞系。凋亡迹象的外观是时间和剂量依赖性的。从流式细胞仪实验中，似乎发生了G0/1上细胞群的延迟。这是第一个报告，即labdane型二萜通过诱导凋亡的相特异性机制杀死肿瘤细胞。

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来源
《Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis》 |1999年第3期|217-234|共18页
作者
Dimas K; Kokkinopoulos D; Demetzos CVaos BMarselos MMalamas MTzavaras T;
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作者单位

Department of Immunology, Hellenic Anticancer Institute, Athens, Greece.;

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原文格式 PDF
正文语种英语
中图分类肿瘤学;
关键词
Cell Line; Cell Cycle Progression; Leukemic CellDiterpenesLeukemiaAntineoplastic Agentssclareol;

机译：细胞系;细胞周期进展;白血病细胞甲甲苯甲藻氨甲状腺素型乳蛋黄酱;

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The effect of sclareol on growth and cell cycle progression of human leukemic cell lines.

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