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首页> 外文期刊>Catalysis science & technology >Recent advances in the transition metal catalyzed carbonylation of alkynes, arenes and aryl halides using CO surrogates
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Recent advances in the transition metal catalyzed carbonylation of alkynes, arenes and aryl halides using CO surrogates

机译：使用CO替代物的炔烃，竞技场和芳基卤化物的过渡金属催化羰基化的最新进展

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摘要

Transition metal catalyzed carbonylation reactions using carbon monoxide as the C-1 source have occupied an all important position in catalysis which is subsequently related to organic synthesis and industrial synthesis of molecules. However, the use of carbon monoxide, an inflammable, toxic greenhouse gas acts as a deterrent to academic and industrial research. Hence, it is imperative to develop a CO-free protocol for promoting sustainable chemistry. The chemistry of CO surrogates has undergone substantial progress with the development of newer reaction methodologies and newer surrogate molecules. Aldehydes, formate esters, formamides, and metal carbonyls have been applied not only to the synthesis of industrial bulk chemicals, but also to the synthesis of specialty chemicals and molecules which are important pharmacological building blocks. Simultaneous development of a two-chamber reactor allows for the ex situ generation of CO and hence circumvents the compatibility issues associated with the substrate and the surrogate during in situ CO generation. Further, the development of specialized surrogate molecules allows for the incorporation of C-13 and C-14-labelled isotopes even at an advanced stage of the synthesis of the molecules. This review thus summarizes the progress in the past decade in the development of synthetic methodologies in which carbonylation reactions are carried out without the use of gaseous carbon monoxide or using carbon monoxide surrogates.
机译：过渡金属使用一氧化碳作为C-1源催化的羰基化反应已占据了催化中的所有重要位置，这随后与有机合成和分子的工业合成有关。但是，使用一氧化碳（一种易燃的有毒温室气体）的使用是对学术和工业研究的威慑作用。因此，必须制定无共同协议来促进可持续化学。随着新反应方法的发展和较新的替代分子的发展，CO替代物的化学经历了实质性进展。醛，甲酸酯，甲酰胺和金属羰基不仅用于合成工业体积化学物质，而且还用于合成特殊的化学品和分子的合成，这些化学物质和分子是重要的药理学基础。同时开发了两腔反应器，因此可以在原位生成期间与底物和替代物相关的兼容性问题，从而避免了原位生成。此外，即使在分子合成的高级阶段，专门的替代分子的发展也可以掺入C-13和C-14标记的同位素。因此，这篇综述总结了过去十年中合成方法论的进展，其中在不使用气态碳一氧化碳或使用一氧化碳替代物的情况下进行了羰基化反应。

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