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首页> 外文期刊>Catalysis science & technology >Combination of gold and iridium catalysts for the synthesis of N-alkylated amides from nitriles and alcohols
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Combination of gold and iridium catalysts for the synthesis of N-alkylated amides from nitriles and alcohols

机译：金和虹膜催化剂的组合，用于合成硝酸盐和醇的N烷基化酰胺

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摘要

An alternative and efficient approach for the synthesis of N-alkylated amides from nitriles and alcohols was proposed and accomplished. By the combination of [(IPr)Au(NTf2)] (IPr = 1,3-bis.diisopropylphenyl)imidazol-2-ylidene) and [Cp*IrCl2](2) (Cp* = eta(5)-pentamethylcyclopentadienyl), a series of nitriles were first hydrated to give amides, in which the resulting amides were further N-alkylated with a variety of alcohols as alkylating agents to afford N-alkylated amides with good to excellent yields. Compared with previous methods for the synthesis of N-alkylated amides from nitriles and alcohols as starting materials, this protocol could be accomplished with high atom economy under more environmentally benign conditions.
机译：提出并完成了一种替代和有效的方法，用于合成N-烷基化酰胺的N-烷基化酰胺。 通过[（IPR）AU（NTF2）]（IPR = 1,3-苯甲酰苯基）咪唑-2-甲基）和[CP* IRCL2]（2）（CP* = ETA（5）-Pentametametametametametametamethylyclopentadadadienylyyyyyyyyyyyyyy-2-3- bis.diisopylphenyl）（iPR = 1,3- bis.diisopylphenyl） - ，首先将一系列硝酸盐水合成酰胺，其中所得的酰胺被多种醇作为烷基化剂进一步N-烷基化，以提供具有良好产量的N-烷基化酰胺。 与以前的氮和醇合成N-烷基化酰胺作为起始材料的方法相比，在更环保条件下，可以在原子经济较高的情况下完成该方案。

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