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首页> 外文期刊>Alzheimer’s & dementia: the journal of the Alzheimer’s Association >Commentary on 'a roadmap for the prevention of dementia II. Leon Thal Symposium 2008.' Primary prevention of dementia in Alzheimer's disease: a perspective from prevention research in cardiovascular disease and stroke.
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Commentary on 'a roadmap for the prevention of dementia II. Leon Thal Symposium 2008.' Primary prevention of dementia in Alzheimer's disease: a perspective from prevention research in cardiovascular disease and stroke.

机译：关于“预防痴呆症的路线图。 阿尔茨海默氏病中痴呆症的主要预防：心血管疾病和中风的预防研究的观点。

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摘要

The current effort to develop disease-modifying drugs that slow the rate of progression of Alzheimer's disease (AD) may not fully address unmet medical needs in the community, because patients remain demented while on therapy. However, an optimized clinical model in which dementia is detected early enough to enable disease-modifying treatments to maintain individuals in the mild stages of AD for a longer period, or to halt the disease at earlier stages, could have clinical value. This degree of efficacy was acceptable to individuals at risk, even if such drugs had considerable side effects [1]. Nevertheless, the primary prevention of dementia is the ultimate goal of drug discovery and development for AD, so that the majority of older persons would die of other causes and never suffer dementia. The key issue is, How do we get there?
机译：目前开发改良疾病的药物的努力减缓了阿尔茨海默氏病进展的速度（AD）可能无法完全满足社区中未满足的医疗需求，因为患者在接受治疗时仍然痴呆。 然而，一个优化的临床模型，在该模型中足够及早检测到痴呆症，以使疾病改良的治疗能够使个体在AD的轻度阶段保持更长的时间，或者在早期阶段停止疾病，可能具有临床价值。 即使这种药物具有相当大的副作用，这种疗效也可以接受风险的个体[1]。 然而，对痴呆症的主要预防是AD药物发现和开发的最终目标，因此大多数老年人会死于其他原因，并且永远不会遭受痴呆症。 关键问题是，我们如何到达那里？

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