The Vitamin D Analog Calcipotriol Combined with Aminolevulinate-Mediated Photodynamic Therapy for Human Psoriasis: A Proof-of-Principle Study

Edward V. Maytin; Golara Honari; Amor Khachemoune

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The Vitamin D Analog Calcipotriol Combined with Aminolevulinate-Mediated Photodynamic Therapy for Human Psoriasis: A Proof-of-Principle Study

机译：维生素D模拟钙三醇与氨基乙酸酯介导的人牛皮癣的光动力疗法结合：一项原则研究证明

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We previously showed that select agents (methotrexate or vitamin D), when administered as a preconditioning regimen, are capable of promoting cellular differentiation of epithelial cancer cells while simultaneously enhancing the efficacy of 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT). In solid tumors, pretreatment with vitamin D simultaneously promotes cellular differentiation and leads to selective accumulation of target porphyrins (mainly protoporphyrin IX, PplX) within diseased tissue. However, questions of whether or not the effects upon cellular differentiation are inexorably linked to PplX accumulation, and whether these effects might occur in hyperprolifer-ative noncancerous tissues, have remained unanswered. In this paper, we reasoned that psoriasis, a human skin disease in which abnormal cellular proliferation and differentia- tion play a major role, could serve as a useful model to test the effects of prodifferentiating agents upon PplX levels in a nonneoplastic setting. In particular, vitamin D, a treatment for psoriasis that restores (i.e., increases) differentiation, might increase PplX levels in psoriatic lesions and facilitate their responsiveness to ALA-PDT. This concept was tested in a pilot study of seven patients with bilaterally matched psoriatic plaques. A regimen in which calcipotriol 0.005% ointment was applied for six days prior to ALA-PDT using blue light led to preferential increases in PplX (ca. 50%), and reductions in thickness, redness, scaling, and itching in the pretreated plaques. The results suggest that a larger clinical trial is warranted to confirm a role for combination treatments with vitamin D and ALA-PDT for psoriasis.

机译：我们先前表明，当作为预处理方案给药时，精选剂（甲氨蝶呤或维生素D）能够促进上皮癌细胞的细胞分化，同时增强5-氨基乙酸（ALA）介导的光动力疗法（PDT）的疗效。在实体瘤中，维生素D的预处理同时促进细胞分化，并导致靶卟啉（主要是原生磷脂IX，PPLX，PPLX）在患病组织中的选择性积累。但是，关于细胞分化的影响是否与PPLX的积累无关的问题，以及这些影响是否可能在超增殖性的非癌组织中发生，但仍未得到解答。在本文中，我们认为牛皮癣是一种人类皮肤疾病，其中异常细胞增殖和差异起主要作用，可以作为一种有用的模型来测试在非塑性环境中生产剂对PPLX水平的影响。特别是，维生素D是恢复（即增加）分化的牛皮癣的治疗方法，可能会增加牛皮癣病变中的PPLX水平并促进其对ALA-PDT的反应性。该概念在一项针对七名双侧匹配的银屑病斑块患者的试点研究中进行了测试。在ALA-PDT之前，使用蓝光在PPLX（大约50％）的优先增加以及厚度，红色，红色，缩放和瘙痒的预定斑块中，使用蓝光施加了0.005％的软膏，在ALA-PDT之前施加了0.005％的软膏。结果表明，有必要进行更大的临床试验，以确认与牛皮癣的维生素D和ALA-PDT的组合治疗作用。

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来源
《Israel journal of chemistry》 |2012年第9期|767-775|共9页
作者
Edward V. Maytin; Golara Honari; Amor Khachemoune;
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作者单位

Department of Dermatology Cleveland Clinic, Cleveland, OH (USA);

Wellman Center for Photomedicine Massachusetts General Hospital Boston, MA (USA);

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正文语种英语
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关键词
photochemistry; Regimen; VitaminsVitamin D Analogcalcipotrienecancer cellPilot StudiesPruritusFluorescenceCell ProliferationProdrugsVitamin DAntineoplastic AgentsPsoriasis;

机译：光化学;方案;维生素维生素D拟南芥cellpiLot struction pruritusfluorescencecell propiferation propodrodrugsvitamin dantineoplasticalspentsperspentsperspentsperspentsperspentsperspentspersperspersperspersisporsissisisis;

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机译：Adu; Aged;; Aged, 80 and over;; Antineoplastic Agents;; Carcinoma, Non-Small-Cell Lung;; Cisplatin;; Cohort Studies;; Deoxycytidine;; Female;; Humans;; Lung Neoplasms;; Male;; Middle Aged;; Mitomycin;; Neoadjuvant Therapy;; Neoplasm Staging;; Pneumonectomy;; Retrospective Studies;; Treatment Outcome;; Vinblastine;; *成年人;; 老年人;; 老年人, 80以上;; 抗肿瘤药;; 癌, 非小细胞肺;; 顺铂;; 队列研究;; 脱氧胞苷;; 肺肿瘤;; 肿瘤辅助疗法;; 肿瘤分期;; 肺切除术;; 回顾性研究;; 治疗结果;; 长春碱

The Vitamin D Analog Calcipotriol Combined with Aminolevulinate-Mediated Photodynamic Therapy for Human Psoriasis: A Proof-of-Principle Study

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