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首页> 外文期刊>Israel journal of chemistry >Label-Free, Longitudinal Visualization of PDT Response In Vitro with Optical Coherence Tomography
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Label-Free, Longitudinal Visualization of PDT Response In Vitro with Optical Coherence Tomography

机译：无标记，纵向可视化PDT反应在体外与光学相干断层扫描

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A major challenge in creating and optimizing therapeutics in the fight against cancer is visualizing and understanding the microscale spatiotemporal treatment response dynamics that occur in patients. This is especially true for photodynamic therapy (PDT), where therapeutic optimization relies on understanding the interplay between factors such as photosensitizer localization and uptake, in addition to light dose and delivery rate. In vitro 3D culture systems that recapitulate many of the biological features of human disease are powerful platforms for carrying out detailed studies on PDT response and resistance. Current techniques for visualizing these models, however, often lack accuracy due to the perturbative nature of the sample preparation, with light attenuation complicating the study of intact models. Optical coherence tomography (OCT) is an ideal method for the long-term, non-perturbative study of in vitro models and their response to PDT. Monitoring the response of 3D models to PDT by time-lapse OCT methods promises to provide new perspectives and open the way to cancer treatment methodologies that can be translated towards the clinic.
机译：在抗癌作斗争中创建和优化治疗剂的主要挑战是可视化和了解患者发生的显微镜时空治疗反应动态。对于光动力疗法（PDT）尤其如此，在该治疗优化中，除了光剂量和递送速度外，还依赖于了解光敏剂定位和摄取等因素之间的相互作用。概括人类疾病的许多生物学特征的体外3D培养系统是对PDT反应和耐药性进行详细研究的强大平台。但是，目前可视化这些模型的技术通常由于样品制备的扰动性质而缺乏准确性，而光衰减使完整模型的研究变得复杂。光学相干断层扫描（OCT）是对体外模型的长期非扰动研究及其对PDT的反应的理想方法。通过延时OCT方法监视3D模型对PDT的响应有望提供新的观点，并为癌症治疗方法开辟了道路，可以将其转化为诊所。

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