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首页> 外文期刊>Annals of work exposures and health. >Skin Notations for Low-Molecular-Weight Amines: Development of a Testing Protocol with Isopropylamine as an Example
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Skin Notations for Low-Molecular-Weight Amines: Development of a Testing Protocol with Isopropylamine as an Example

机译：低分子量胺的皮肤符号：以异丙胺为例开发测试方案

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Owing to their volatility, the most important occupational exposure route for low-molecular-weight amines is considered to be inhalation. However, dermal exposure is also possible in many workplace situations. There are limited data available on the dermal uptake of these amines through human skin, and existing exposure standard skin notations are typically based on acute toxicity animal studies or by chemical analogy. This gap in knowledge is in part due to a lack of standardized approach for assessing dermal uptake. We describe a relatively simple protocol for the determination of permeation of low-molecular-weight amines through human skin in vitro. Using isopropylamine as a test amine, it was found that isopropylamine vapour has limited capacity to absorb into, or penetrate through, the epidermal layer of human skin, even at lethal atmospheric concentrations. This protocol can be adapted for a range of exposure scenarios, including clothing effects, and may be used to determine whether skin notations are warranted.
机译：由于其波动性，低分子量胺的最重要的职业曝光途径被认为是吸入。但是，在许多工作场所情况下，皮肤的暴露也可以。关于这些胺通过人体皮肤摄取的真皮摄取的数据有限，现有的暴露标准皮肤符号通常基于急性毒性动物研究或化学类比。知识的差距部分是由于缺乏评估皮肤摄取的标准化方法。我们描述了一种相对简单的方案，用于确定在体外人类皮肤中低分子量胺的渗透。使用异丙胺作为测试胺，发现异丙基胺蒸气的吸收能力有限，即使在致命的大气浓度下，也可以吸收或穿过人类皮肤的表皮层。该协议可以针对各种曝光场景（包括服装效果）进行调整，并可用于确定是否有必要进行皮肤符号。

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