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首页> 外文期刊>Scientia Africana: An International Journal of Pure & Applied Sciences >EFFECT OF ETHANOL EXTRACT OF THE FRUITING BODIES OF PLEOROTUS OSTREATUS ON THE SERUM HEPATO-SPECIFIC ENZYME MARKERS AND LIVER HISTOLOGY OF HIGH SUCROSE-HIGH FAT DIET-STREPTOZOTOCIN INDUCED DIABETIC RATS
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EFFECT OF ETHANOL EXTRACT OF THE FRUITING BODIES OF PLEOROTUS OSTREATUS ON THE SERUM HEPATO-SPECIFIC ENZYME MARKERS AND LIVER HISTOLOGY OF HIGH SUCROSE-HIGH FAT DIET-STREPTOZOTOCIN INDUCED DIABETIC RATS

机译：胸膜油骨的乙醇提取物的乙醇提取物对高蔗糖高脂肪饮食饮食诱导的糖尿病大鼠的血清肝特异性酶标记和肝组织学的影响

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摘要

The effect of ethanol extract of the fruiting bodies of Pleurotusostreatus on the serum hepato-speciftc enzyme markers and liver histology were determined in high sucrose-high fat diet-streptozotocin induced diabetic rats. The pharmacological model was 20% High Sucrose (HS) + 20% High Fat Diet (HFD) + 35mg/kg body weightt (intraperitoneal) Streptozotocin (STZ) induced diabetic rat model, with the fruiting body ethanol extracts administered orally at 50, 150 and 300mg/kg b.w. After 6 weeks of treatment, alkaline phosphatase activity (ALP) of the treated groups and the reference treatment groups were significantly (p0.05) from the normal control. At the end of 9 weeks of treatment, the ALT activity of the diabetic group treated with fruiting body ethanol extract at 300mg/kg b.w. and diabetic group treated with fruiting body ethanol extract at 50mg/kg b.w. were significantly lower (p<0.05) than the D group although not significantly different than the normal control.The extract at 300mg/kg b.w. reversed the fatty liver and periportalinflammation caused by HS-HFD-streptozotocin induced diabetes in the rats to normal, indicatingdose dependent protective effects of the extract against HS-HFD-streptozotocin induced hepatotoxicity alterations. The reduction in the serum levels of these liver enzymes by the extract suggests that they may be used to reverse the incidence of liver function test irregularities common in diabetic patients. The results suggest that ethanol extract of fruiting bodies of Pleurotusostreatus may be employed in the management of liver diseases associated with diabetes mellitus.
机译：在高蔗糖高脂肪饮食饮食诱导的糖尿病大鼠中，确定了胸膜肌酸成果体的乙醇提取物对肝素肝菌株标记和肝组织学的影响。药理学模型为20％高蔗糖（HS） + 20％高脂肪饮食（HFD） + 35mg/kg体重（腹膜内）链蛋白酶（STZ）诱导的糖尿病大鼠模型，并在50、150、150，150、150，以500、150的体外给药。和300mg/kg B.W.经过6周的治疗后，治疗组的碱性磷酸酶活性（ALP）和参考治疗组显着（P 0.05）。在治疗的9周结束时，糖尿病组的ALT活性在300mg/kg b.w. B.W.中用水果体乙醇提取物治疗。和以50mg/kg B.W.的水果体乙醇提取物处理的糖尿病组尽管与正常对照没有显着差异，但比D组显着低（P <0.05）。提取物为300mg/kg b.w.由HS-HFD-链接受蛋白诱导的大鼠糖尿病引起的脂肪肝和外周炎，表明提取物依赖于HS-HFD-链接受性的肝素诱导的肝毒性改变。提取物通过提取物的血清水平降低表明，它们可用于扭转糖尿病患者常见的肝功能测试不规则性的发生率。结果表明，胸膜治疗的乙醇提取物可以用于与糖尿病相关的肝病治疗。

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