Effective CD4 T cell priming requires repertoire scanning by CD301b+ migratory cDC2 cells upon lymph node entry

NAOYA TATSUMI; ALICIA L. CODRINGTON; JIHAD EL-FENEJ

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Effective CD4 T cell priming requires repertoire scanning by CD301b+ migratory cDC2 cells upon lymph node entry

机译：有效的CD4 T细胞启动需要在淋巴结进入时通过CD301B+迁移CDC2细胞扫描曲目

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During the initiation of adaptive immune responses, millions of lymphocytes must be scanned to find the few cognate clones. The activation mechanisms of CD4 T cells have been extensively studied, but the cellular mechanisms that drive selection of cognate clones are not completely understood. Here, we show that recently homed naive polyclonal CD4 T cells are temporarily retained before leaving the lymph node. This stop-and-go traffic of CD4 T cells provides an adequate time window for efficient scanning and timely priming of antigen-specific cognate clones. CD301b+ DCs, a major subset of migratory cDC2 cells, localize to the areas around high endothelial venules, where they retain incoming polyclonal CD4 T cells through MHCII-dependent but antigen-independent mechanisms, while concurrently providing cognate stimuli for priming. These results indicate that CD301b+ DCs function as an immunological “display window” for CD4 T cells to efficiently scan their antigen specificity.

机译：在开始自适应免疫反应期间，必须扫描数百万个淋巴细胞以找到少数同源克隆。已经对CD4 T细胞的激活机制进行了广泛的研究，但是尚未完全了解驱动相关克隆选择的细胞机制。在这里，我们表明，最近在离开淋巴结之前暂时保留了最近的幼稚多克隆CD4 T细胞。 CD4 T细胞的这种停止流量为有效扫描和及时启动抗原特异性同源克隆提供了足够的时间窗口。 CD301B+ DC是迁移CDC2细胞的主要子集，位于高内皮静脉周围的区域，在那里它们通过MHCII依赖性但不依赖于抗原的机制保留传入的多克隆CD4 T细胞，同时为启动启动提供相关刺激。这些结果表明，CD301B+ DCS充当CD4 T细胞的免疫“显示窗口”，可有效扫描其抗原特异性。

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《Science Immunology》 |2021年第66期|Effective CD4 T/1-Effective CD4 T/17|共17页
作者
NAOYA TATSUMI; ALICIA L. CODRINGTON; JIHAD EL-FENEJ;
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Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA;

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正文语种英语
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关键词
T-Lymphocytes; CD4 Antigens; Lymph NodesCoatingantigen specificityscanningClone Cells;

机译：T-淋巴细胞;CD4抗原;淋巴结蛋白抗原特异性细胞细胞;

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Effective CD4 T cell priming requires repertoire scanning by CD301b+ migratory cDC2 cells upon lymph node entry

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