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Sleep duration and risk of cancer in the Mexican American Mano-a-Mano Cohort

机译：墨西哥裔美国人Mano-A-Mano队列的睡眠时间和癌症风险

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Background: To date, no study has investigated the association of sleep duration with cancer risk in Mexican Americans. Analysis: Using data from the Mano-A-Mano Mexican American Cohort study, we analyzed the relationship between sleep duration and overall cancer risk among Mexican Americans. Results: Of 10,802 subjects included in this study, 429 developed cancer during follow-up. Compared with study participants sleeping 8-9 hours per night, those sleeping less than 6 hours per night had significantly increased risk of overall cancer in both univariate and multivariate Cox regression analyses. After adjusting for social-demographic and lifestyle variables, sleeping less than 6 hours per night was associated with a 1.37-fold increased risk of overall cancer (hazard ratio = 1.37, 95% confidence interval: 1.01-1.97). In breast cancer alone, sleeping less than 6 hours per night was associated with a 1.86-fold increased risk of breast cancer (hazard ratio = 1.86, 95% confidence interval: 1.01-3.45) after adjustment for birthplace and language acculturation. In further stratified analysis, significant associations between sleeping less than 6 hours per night and overall cancer risk were evident among overweight participants, former drinkers, those with medium or high levels of physical activity, those married or living together, and those who had less than 2 hours of sitting time per day. In addition, increased cancer risk associated with long sleep duration (at least 9 hours per night) was observed among overweight participants and those with medium or high levels of physical activity. Conclusion: Our results provide evidence to link sleep duration with cancer risk among Mexican Americans.
机译：背景：迄今为止，尚无研究调查墨西哥裔美国人的睡眠持续时间与癌症风险的关联。分析：使用Mano-A-Mano墨西哥裔美国队列研究的数据，我们分析了墨西哥裔美国人的睡眠时间与总体癌症风险之间的关系。结果：在这项研究中包括10,802名受试者中，有429名在随访期间出现了癌症。与研究参与者每晚睡眠8-9个小时相比，每晚睡眠不到6个小时的人在单变量和多元COX回归分析中都显着增加了总体癌症的风险。在调整了社会人口统计学和生活方式变量之后，每晚睡眠不到6小时与总癌症的风险增加1.37倍（危险比= 1.37，95％置信区间：1.01-1.97）。仅在乳腺癌中，每晚睡眠不到6个小时就与乳腺癌的风险增加了1.86倍（危险比= 1.86，95％置信区间：1.01-3.45）在调整出出生地和语言适应性后。在进一步的分层分析中，超重参与者，前饮酒者，中等或高水平的体育锻炼，已婚或生活的人以及那些小于小于小于每天2个小时的坐时间。此外，在超重参与者中观察到与长时间睡眠持续时间相关的癌症风险增加（每晚至少9个小时），并且患有中等或高水平的体育锻炼患者。结论：我们的结果为墨西哥裔美国人的睡眠时间与癌症风险联系起来提供了证据。

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