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首页> 外文期刊>Otology and neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology >Administration of the Combination Clonazepam-Deanxit as Treatment for Tinnitus
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Administration of the Combination Clonazepam-Deanxit as Treatment for Tinnitus

机译：组合氯硝西epam-抑制作为耳鸣的治疗

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Hypothesis: Present study investigates the combination of Deanxit and clonazepam (Rivotril) intake for relief of tinnitus complaints, respecting a double-blind placebo-controlled approach for Deanxit in a crossover setup. Background: Although several pharmacologic treatments-including antidepressants, prostaglandins, and aminobutyric acid (GABA)-active drugs-were already presented as promising in tinnitus treatment, no drug has yet been approved by the Food and Drug Administration and European Medicine Agency for the treatment of tinnitus.Methods: Patients were randomly assigned to patient group A or patient group B in a double-blind way. Patient group A first received 3 weeks of Deanxit, followed by 1 week of washout and 3 weeks of placebo. Treatment was given in opposite order to subjects from Patient group B. All patients received a daily treatment consisting of clonazepam 1 mg once daily, starting on Day 1.Results: Significant tinnitus reduction was seen after intake of the combination clonazepam-Deanxit, whereas no differences in tinnitus could be demonstrated after the administration of clonazepam-placebo. This was true for all patients according to the following parameters: time patients are annoyed by the tinnitus (p = 0.026) and the visual analogue scale for tinnitus annoyance (p = 0.024).Conclusion: Although tinnitus reduction was recorded as modest, this article provides valuable data demonstrating a placebo-controlled tinnitus reduction after clonazepam and Deanxit intake.
机译：假设：目前的研究调查了DeAnxit和氯硝西ep（Rivotril）摄入量以缓解耳鸣依据，并尊重在交叉设置中采用双盲安慰剂对照方法。背景：尽管几种药理学疗法 - 包括抗抑郁药，前列腺素和氨基丁酸（GABA）活性药物，但在耳鸣治疗中已经有希望的药物，但尚未获得食品和药物管理局和欧洲医学局的批准tinnitus.methods：以双盲方式将患者随机分配给患者A组或B组。患者A组首先获得了3周的脱发，然后进行1周的洗涤和安慰剂3周。与患者组的受试者相反的治疗。所有患者每天接受每天1 mg 1 mg的治疗，从第1天开始进行。分析：在摄入氯硝西epam- deanxit的摄入后，观察到明显的耳鸣降低，而无需降低耳鸣。在给药后，可以证明耳鸣的差异。根据以下参数，所有患者都是如此：时间患者被耳鸣（p = 0.026）和耳鸣烦恼的视觉模拟量表感到烦恼（p = 0.024）。结论：尽管记录了小气含耳鸣，但记录了谦虚，这是谦虚的，这篇文章，这篇文章提供有价值的数据，证明了氯硝西ep和deanxit摄入后的安慰剂对照耳鸣的减少。

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