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Probing residual vestibular function with galvanic stimulation in vestibular loss patients.

机译:在前庭损失患者中探测残留的前庭功能。

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摘要

INTRODUCTION: : Galvanic vestibular stimulation (GVS) was used to probe the residual vestibular function in unilateral vestibular loss. METHODS: : 39 control subjects, 60 patients areflexic to caloric tests, 21 patients with pre-operative acoustic neurinoma, and 26 patients with surgical deafferentation were tested with 4mA trapezoidal GVS. Horizontal slow phase velocity and vertical slow phase velocity components of the slow phase of induced nystagmus were recorded with videonystagmography. RESULTS: : All patients had lower horizontal slow phase velocity compared with intact subject. In caloric areflexic patients, the intact ear responded similarly to controls. The lesioned ear was less excitable but could be inhibited as in controls. In patients with acoustic neurinoma, the intact ear was normally excitable but less sensitive to inhibition. The lesioned ear, although not excitable, could be inhibited. In patients with surgical deafferentation, the intact ear could be barely excited and not inhibited. The lesioned ear could not be excited but slightly inhibited. These results fit well with previous data in animal models after unilateral vestibular loss. CONCLUSION: : Unilateral vestibular patients exhibit a progressive deterioration of the horizontal canal function, corresponding to 4 different patterns of GVS response. This study confirms that GVS is useful to probe evolution of the residual vestibular function in patients.
机译:简介::使用单侧前庭损失中的残留前庭功能来探测残留的前庭功能。方法:: 39例对照受试者,60例患者对热量测试,21例术前声学神经瘤患者,并用4MA梯形GVS测试了26例手术性术患者。通过视频播放记录了诱导的眼球震颤慢相的水平慢相速度和垂直慢相速度成分。结果::与完整受试者相比,所有患者的水平缓慢速度较低。在卡路里是富裕的患者中,完整的耳朵对对照的反应类似。病变的耳朵不那么兴奋,但可以像对照组一样抑制。在患有声学神经瘤的患者中,完整的耳朵通常可激发,但对抑制作用不太敏感。病变的耳朵虽然不可兴奋,但可以抑制。在手术脱落的患者中,完整的耳朵几乎不会受到兴奋,也不会抑制。病变的耳朵不会被激发,但会稍微抑制。这些结果与单侧前庭丧失后动物模型中的先前数据非常吻合。结论::单侧前庭患者表现出水平运河功能的进行性恶化,对应于4种不同的GVS反应模式。这项研究证实,GVS可用于探测患者残留前庭功能的演变。

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