Prospective randomized trial of neoadjuvant chemotherapy during the ‘wait period’ following preoperative chemoradiotherapy for rectal cancer: results of the WAIT WAIT trial

Moore J.; Price T.; Carruthers S.Selva‐Nayagam S.Luck A.Thomas M.Hewett P.

首页> 外文期刊>Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland >Prospective randomized trial of neoadjuvant chemotherapy during the ‘wait period’ following preoperative chemoradiotherapy for rectal cancer: results of the WAIT WAIT trial

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Prospective randomized trial of neoadjuvant chemotherapy during the ‘wait period’ following preoperative chemoradiotherapy for rectal cancer: results of the WAIT WAIT trial

机译：新辅助chemot的前瞻性随机试验herapy preopera后在“等待期”有效化疗对直肠癌:结果的等待等待审判

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Abstract Aim The aim was to determine whether the addition of additional cycles of chemotherapy during the ‘wait period’ following neoadjuvant chemoradiotherapy for rectal cancer improves the pathological complete response ( pCR ) rate. Method Rectal cancer patients were randomly allocated either to a standard 10?week wait period before surgery (standard chemoradiotherapy, SCRT ) or to receive three cycles of fluorouracil based chemotherapy following chemoradiotherapy during a similar 10?week wait (extended chemoradiotherapy, XCRT ). The primary end‐point was pCR as determined by blinded pathological assessment. Results Forty‐nine patients were randomized ( SCRT n? = ? 24, XCRT n? = ? 25). pCR occurred in 10 patients overall but there was no significant difference in pCR between the groups ( SCRT n? = ? 6, XCRT n? = ? 4, P? = ? 0.49). Conclusion The addition of three cycles of 5‐fluorouracil/leucovorin in a 10?week wait period after conventional chemoradiotherapy seems to result in similar pCR rates in patients with locally advanced rectal cancer based on this small randomized trial.

机译：抽象的目的是确定目标添加额外的周期的化疗在“等待期”后新辅助化疗对直肠癌提高了病理完全缓解(pCR)率。直肠癌患者被随机方法分配标准10 ?手术前(标准化疗,SCRT)或接受三个氟尿嘧啶为基础的化疗周期在化疗期间相似10？主要终端点是由pCR蒙蔽病理评估。四十》9名患者被随机分配(SCRT n ?24日,XCRT n ?但是没有显著性差异在pCR组(n SCRT ?n ?三个周期的5氟尿嘧啶/亚叶酸应承担的10？化疗似乎导致类似的pCR局部晚期患者直肠基于这个小随机试验的癌症。

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《Colorectal disease: the official journal of the Association of Coloproctology of Great Britain and Ireland》 |2017年第11期|973-979|共7页
作者
Moore J.; Price T.; Carruthers S.Selva‐Nayagam S.Luck A.Thomas M.Hewett P.;
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作者单位

Department of SurgeryUniversity of AdelaideAdelaide,South Australia,Australia;

Department of Colorectal SurgeryLyell McEwen Health ServiceAdelaide,South Australia,Australia;

Department of Medical OncologyQueen Elizabeth HospitalAdelaide,South Australia,AustraliaDepartment of Colorectal SurgeryRoyal Adelaide HospitalAdelaide,South Australia,AustraliaDepartment of Medical OncologyRoyal Adelaide HospitalAdelaide,South Australia,AustraliaDepartment of Radiation OncologyRoyal Adelaide HospitalAdelaide,South Australia,Australia;

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正文语种英语
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Chemoradiotherapy; Cancer of Rectum; Randomized Controlled TrialClinical Trials, RandomizedAdjuvant Chemotherapypreoperative chemotherapy;

机译：化疗;直肠癌症;随机TrialClinical控制试验,RandomizedAdjuvant Chemotherapypreoperative化疗;

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Prospective randomized trial of neoadjuvant chemotherapy during the ‘wait period’ following preoperative chemoradiotherapy for rectal cancer: results of the WAIT WAIT trial

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