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首页> 外文期刊>Current Protocols in Microbiology >In Vitro Culturing and Screening ofCandida albicans Biofilms
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In Vitro Culturing and Screening ofCandida albicans Biofilms

机译：体外培养和筛选ofCandida念珠菌生物膜

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摘要

Candida albicans is a normal member of the human microbiota that asymptomaticallycolonizes healthy individuals, however it is also an opportunisticpathogen that can cause severe infections, especially in immunocompromisedindividuals. The medical impact of C. albicans depends, in part, on its abilityto form biofilms, communities of adhered cells encased in an extracellularmatrix. Biofilms can form on both biotic and abiotic surfaces, such as tissuesand implanted medical devices. Once formed, biofilms are highly resistant toantifungal agents and the host immune system, and can act as a protected reservoirto seed disseminated infections. Here, we present several in vitro biofilmprotocols, including protocols that are optimized for high-throughput screeningof mutant libraries and antifungal compounds. We also present protocolsto examine specific stages of biofilm development and protocols to evaluateinterspecies biofilms that C. albicans forms with interactingmicrobial partners.
机译：白色念珠菌是一种正常的人类微生物群asymptomaticallycolonizes健康个人,不过这也是一个opportunisticpathogen可以引起严重的感染,特别是在immunocompromisedindividuals。白念珠菌的部分取决于它的能力形成生物膜,粘附细胞的社区包裹在一个extracellularmatrix。生物和非生物的表面形式,如tissuesand植入医疗设备。生物膜形成,是高度耐药toantifungal代理和宿主的免疫系统,和可以作为保护reservoirto种子传播感染。体外biofilmprotocols,包括协议针对高通量进行了优化screeningof突变体库和抗真菌化合物。生物膜发展的特定阶段协议evaluateinterspecies生物膜白念珠菌与interactingmicrobial形式合作伙伴。

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