Building (Viral) Phylogenetic Trees Usinga Maximum Likelihood Approach

Kelly M. King; Koenraad Van Doorslaer

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Building (Viral) Phylogenetic Trees Usinga Maximum Likelihood Approach

机译：使用最大建筑(病毒)系统发育树可能的方法

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Phylogenetic analyses allow for inferring a hypothesis about the evolutionaryhistory of a set of homologous molecular sequences. This hypothesis can beused as the basis for further molecular and computational studies. In this unit,we offer one specific method to construct a Maximum Likelihood phylogenetictree. We outline how to identify homologous sequences and constructa multiple sequence alignment. Following alignment, sequences are screenedfor potentially confounding factors such as recombination and genetic saturation.Finally, a Maximum Likelihood phylogenetic tree can be constructedimplementing a rigorously tested model of evolution. The workflow outlinedin this unit provides sufficient background for inferring a robust phylogenetictree starting from a particular gene of interest.

机译：系统发育分析允许推断假设的evolutionaryhistory集同源分子序列。假设可以用来进一步的基础分子和计算研究。单位,我们提供一个特定的方法来构造一个最大似然phylogenetictree。如何识别同源序列和constructa多重序列比对。对齐,序列是screenedfor可能如复合和混杂因素基因饱和。系统树可以constructedimplementing一个严格的测试模型的进化。工作流outlinedin这个单位提供足够的背景一个健壮的推断是正确的phylogenetictree从一个特定的基因感兴趣的。

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来源
《Current Protocols in Microbiology》 |2018年第1期|e63/1-e63/24|共24页
作者
Kelly M. King; Koenraad Van Doorslaer;
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作者单位

School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson,Arizona;

Department of Immunobiology, Cancer Biology Graduate Interdisciplinary Program,Genetics Graduate Interdisciplinary Program, BIO5 Institute, and the University ofArizona Cancer Center, University of Arizona, Tucson, Arizona;

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正文语种英语
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viruses; Sequence Alignment; Saturatedmaximum likelihoodPhylogenyHomologous Sequences;

机译：病毒,序列比对;SaturatedmaximumlikelihoodPhylogenyHomologous序列;

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Building (Viral) Phylogenetic Trees Usinga Maximum Likelihood Approach

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