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首页> 外文期刊>Deutsche Zeitschrift fur Sportmedizin >Rekombinantes und endogen produziertes Wachstumshormon wirken unterschiedlich auf das IGF1 System
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Rekombinantes und endogen produziertes Wachstumshormon wirken unterschiedlich auf das IGF1 System

机译：Rekombinantes和endogen produziertes生长激素的作用差异IGF1系统

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摘要

To evaluate the effects of endogenously (exercise) and exogenously (recombinant hGH) induced increased human growth hormone (hGH) levels on the anabolic IGF1 system, we investigated 6 male subjects (24.8 ± 3.0 yrs) under three randomized conditions: 1. control conditions (C); 2. after 1h cycle er-gometer exercise at 60% of max. performance (E); 3. after injection of 4 IU rhGH (rhGH, with permission of the local ethic committee). All experiments started at 4 p.m. lasting in total 24h. Blood samples were taken every 20 min from a central venous catheter. Sleep was controlled by EEG. Mean 24h [hGH] were increased during E (2.83 ± 0.99 ng/ml) and during rhGH (3.59 ± 0.52 ng/ml) when compared to C (0.97 ± 0.37 ng/ml). [IGF1] slightly decreased during C and E, but it increased during I (from 171.3 ±51.0 to 251.4 ± 84.5 ng/ml). BP1 increased after exercise (from 20.7 ± 3.8 to 70.1 ± 24.7 ng/ml), whereas BP3 was significantly lower during E than during rhGH. Probably as an effect of increased [IGF1], [urea] was lower during rhGH (from 5.0 ±0.4 to 3.2 ±0.5 mmol/l) than during C and E. The systemic IGF1 system is not influenced by exercise induced increased plasma [hGH], but it is strongly stimulated by exogenously achieved high hGH levels.
机译：从内部评估的影响(运动)重组和体内(hGH)诱导增加人体生长激素(hGH)水平合成代谢IGF1系统,我们调查了6男主题三个随机的(24.8±3.0岁)条件:1。1 h周期er-gometer运动最大的60%。性能(E);(rhGH当地伦理许可委员会)。持续24小时。每20分钟从中央静脉导管。睡眠脑电图所控制。增加在E(2.83±0.99 ng / ml)和期间rhGH(3.59±0.52 ng / ml)相比,C (0.97±0.37 ng / ml)。和E,但它在我(从171.3增加±51.0,251.4±84.5 ng / ml)。运动(从20.7±3.8,70.1±24.7 ng / ml),而在E BP3明显低于在rhGH。(IGF1),(尿素)是在rhGH(从5.0降低±0.4,3.2±0.5更易与比在C和e / l)系统性IGF1系统并没有影响锻炼诱导增加等离子体(hGH),但它强烈刺激体内实现高hGH的水平。

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