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Self-reported sleep characteristics and risk for incident vertebral and hip fracture in women

机译：自我报告的睡眠特征和风险事件脊椎和髋部骨折的女性

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Objective: To examine the relationships between self-reported sleep characteristics and risk of incident vertebral fracture and hip fracture in women. Design: Longitudinal cohort study. Setting: Nurses' Health Studies (NHS: 2002-2014, NHSII: 2001-2015). Participants: Total 122,254 female registered nurses (46,129 NHS, 76,125 NHSII) without prior history of fracture. Exposure: Sleep was characterized by 4 sleep-related domains-sleep duration, sleep difficulty, snoring, and excessive daytime sleepiness-assessed by self-reported questionnaires. Outcomes: Self-reports of vertebral fracture were confirmed by medical record review and hip fracture was assessed by biennial questionnaires. Results: Over 12-14 years of follow-up, 569 incident vertebral fracture cases (408 in NHS, 161 in NHSII) and 1,881 hip fracture cases (1,490 in NHS, 391 in NHSII) were documented. In the pooled analysis, the multivariable-adjusted HR (95% CI) for vertebral fracture was 1.20 (0.86, 1.66) for sleep duration 9 vs. 7 hours; 1.63 (0.93, 2.87) for sleep difficulties all-the-time vs. none/little-ofthe-time (p-trend = 0.005); 1.47 (1.05, 2.05) for snoring every night/week vs. never/occasionally (p trend = 0.03), and 2.20 (1.49, 3.25) for excessive daytime sleepiness daily vs. never (p-trend < 0.001). In contrast, associations were not observed with hip fracture risk. Conclusion: Poorer sleep characteristics were associated with risk of vertebral fracture. Our study highlights the importance of multiple dimensions of sleep in the development of vertebral fractures. Further research is warranted to understand the role of sleep in bone health that may differ by fracture site, as well as sleep interventions that may reduce the risk of fracture. Published by Elsevier Inc. on behalf of National Sleep Foundation.
机译：目的:研究之间的关系自我报告的睡眠特点和风险事件脊椎骨折,髋部骨折女性。设置:护士健康研究(NHS: 2002 - 2014,NHSII: 2001 - 2015)。女性注册护士(46129年NHS, 76125NHSII)事先断裂的历史。曝光:睡眠的特点是4睡眠domains-sleep持续时间、睡眠困难,打鼾,白天sleepiness-assessed的自述问卷。椎骨折经体检记录审查和评估了髋部骨折两年一次的问卷调查。年的随访中,569事件椎骨折情况下(161年408年NHS, NHSII)和1881例髋部骨折病例(1490年的国民健康保险制度,391年NHSII)记录。multivariable-adjusted人力资源(95% CI)椎体骨折是1.20 (0.86,1.66)睡眠时间 9和7个小时;2.87)对睡眠困难自始至终vs。没有/ little-ofthe-time (p-trend = 0.005);(1.05, 2.05),每天晚上打鼾/ vs。从不/偶尔趋势(p = 0.03),和2.20日间极度嗜睡(1.49,3.25)每日与从未(p-trend < 0.001)。协会与髋部骨折并没有观察到风险。与脊椎骨折的风险有关。我们的研究强调了多次的重要性发展的维度的睡眠椎体骨折。保证理解睡在骨的作用健康可能不同的骨折处睡眠干预措施,可以减少风险的骨折。国家睡眠基金会。

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