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NON-INVASIVE CANCER-Role of radiotherapy boost in women with ductal carcinoma in situ: A single-center experience in a series of 389 patients

机译：非侵入性的CANCER-Role放疗增加导管原位癌的女性:一个在389年的一系列单中心经验病人

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Background.-The use of adjuvant radiotherapy in ductal carcinoma in situ is accepted by most radiation oncologists worldwide; the role of a boost on the tumor bed is however more controversial. Materials and Methods. -We reviewed our Institute experience in DCIS treatment, focusing on main prognostic factors and impact of radiation boost on local relapse. A total of 389 patients treated between 1990 and 2007 were retrospectively analyzed. All patients received adjuvant radiotherapy after breast-conserving surgery for a median dose of 50 Gy; 190 patients (48.8%) received and additional radiation boost on the tumor bed. Results.-At a mean follow up of 7.7 years, we recorded 26 local recurrence (6.7%). Concerning local relapse-free survival, at Cox regression univariate analyses <1 mm surgical margins (p< 0.0001) and young age (p = 0.01) emerged as significant unfavorable prognostic factors. At multivariate analysis Cox regression model, surgical margins (p< 0.001) and radiation boost (p = 0.014) resulted as the significant independent predictors of recurrence.
机译：背景。导管原位癌是被大多数接受放射肿瘤学家全球;促进肿瘤床上但是更多有争议的。回顾了我们学院DCIS的经验治疗,关注主要预后因素的辐射和影响推动当地复发。1990年间共有389名患者治疗2007年进行回顾性分析。收到辅助放疗后采用中等剂量的50Gy;辐射增强肿瘤床上。平均7.7年的随访,记录当地26复发(6.7%)。生存,在单变量Cox回归分析< 1毫米外科利润率(p < 0.0001)和年轻的年龄(p = 0.01)成为重大不利预后因素。回归模型、外科利润率(p < 0.001)辐射增强(p = 0.014)造成的重要的复发的独立预测指标。

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