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首页> 外文期刊>Polymer chemistry >Asymmetrically functionalized 0-cyclodextrin-based star copolymers for integrated gene delivery and magnetic resonance imaging contrast enhancement
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Asymmetrically functionalized 0-cyclodextrin-based star copolymers for integrated gene delivery and magnetic resonance imaging contrast enhancement

机译：不对称功能化0-cyclodextrin-based星综合基因传递和共聚物磁共振成像对比度增强

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摘要

We report on the synthesis of star copolymers possessing dual functions of gene delivery vectors and magnetic resonance (MR) imaging contrast enhancement. Starting from asymmetrically functionalized β-cyclodextrin (β-CD) comprising 7 azide moieties and 14 α-bromopropionate functionalities at the upper and lower rim of a rigid toroidal β-CD core, (DOTA-Gd)_7-CD-(PDMA)_(14) star copolymers were synthesized via atom transfer radical polymerization (ATRP) of N,N-dimethylaminoethyl methacrylate (DMA) and subsequent click reaction with an alkynyl-functionalized gadolinium (Gd~(3+)) complex, DOTA-Gd, where DOTA is 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. The obtained Janus-type star copolymers, (DOTA-Gd)_7-CD-(PDMA)_(14), could completely complex with anionic plasmid DNA (pDNA) via electrostatic interactions at N/P ratios equal to or higher than 2 and exhibit optimal in vitro transfection efficiency at an N/P ratio of 8. In addition, in vitro MR imaging experiments demonstrated considerably enhanced T1 relaxivity (r1 ～ 10.9 s~(-1) mM~(-1)) for the star copolymer compared to that of commercially available small molecular MR imaging contrast agents (2.4-3.2 s~(-1) mM~(-1)). The star-type topology of asymmetrically functionalized β-CD based copolymers in combination with the integrated design of diagnostic and therapeutic functions augurs well for their potential applications in the field of image-guided gene therapy.
机译：我们报道了星型共聚物的合成拥有双基因传递的函数向量和磁共振(MR)成像对比度增强。不对称功能化β环糊精叠氮化(βcd)由7根和14α-bromopropionate功能上和较低的边缘的刚性环形βcd核心,(DOTA-Gd) _7-CD - (PDMA) _(14)星型共聚物通过原子转移自由基合成聚合(ATRP)的N, N-dimethylaminoethyl丙烯酸甲酯(DMA)和随后的点击反应与一个alkynyl-functionalized钆(Gd ~(3 +))复杂,DOTA-Gd,队伍在哪里

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