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首页> 外文期刊>Vegetos: an international journal of plant research >Enzymatic treatment improves ACE-I inhibiton and antiproliferative potential of chickpea
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Enzymatic treatment improves ACE-I inhibiton and antiproliferative potential of chickpea

机译：酶治疗改善ACE-I inhibiton和抗增殖潜能的鹰嘴豆

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摘要

Chickpea seeds are the preferred source of proteins possessing health care functions in countries across the world. Study indicated the chickpea proteins as a promising center of bioactive peptides and open up new vista for food industry. Employing gastrointestinal enzyme alcalase, protein hydrolysates generated from 45 chickpea seed accessions were evaluated for angiotensin-I converting enzyme (ACE-I) inhibitory potential and antiproliferative influence. Alcalase at 1 h of optimum hydrolysis produced bioactive peptides inhibiting the ACE-I activity. The accession BDN-9-3 gave highest ACE-I inhibitory activity with IC_(50) value of 22.43 mg/ml. The protein hydrolysate of BDN-9-3 was further subjected to antiproliferative assessment against breast cancer cells MCF-7 and MDA-MB-231. The IC_(50) of BDN-9-3 alcalase hydrolysate was 0.60 mg/ml and 0.63 mg/ml in MCF-7 and MDA-MB-231 cells respectively, compared to non hydrolyzed chickpea protein (IC_(50) of 0.85 and 0.82 mg/ml). Present study ascertain that chickpea seed hydrolysate can be perceived as a valuable nutraceutical resource.
机译：鹰嘴豆种子的首选源蛋白质具有保健功能国家在世界各地。鹰嘴豆蛋白是一个有前途的中心生物活性肽和开辟新的vista行业。从45 alcalase,蛋白玉米胚芽蛋白酶解物生成鹰嘴豆种子到达进行评估血管紧张转换酶(ACE-I)抑制潜力和抗增殖的影响力。生物活性肽抑制ACE-I生产活动。ACE-I抑制活动IC_(50)值22.43毫克/毫升。进一步进行抗增殖吗对乳腺癌细胞MCF-7和评估mda - mb - 231。水解为0.60毫克/毫升和0.63毫克/毫升MCF-7和mda - mb - 231细胞,分别比较非水解鹰嘴豆蛋白(IC_ (50)0.85和0.82毫克/毫升)。水解,鹰嘴豆种子可以感知作为一个有价值的营养食品资源。

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