NAD+ controls neural stem cell fate in the aging brain

WileyC.; CampisiJ.

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NAD+ controls neural stem cell fate in the aging brain

机译：NAD +控制神经干细胞命运的衰老过程大脑

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Loss of the coenzyme NAD+, which is required for many energy-dependent cellular processes, has emerged as a potentially unifying mechanism for age-related conditions. A study in this issue of The EMBO Journal identifies a novel link between depletion of NAD+ and age-associated loss of proliferating adult neural stem/progenitor cells in the murine brain (Stein & Imai,). These data have important implications for how brain function might decline with age. Age-associated loss of NAD+ or Nampt, the rate-limiting biosynthetic step for this coenzyme, accounts for the loss of neural stem/progenitor cells self-renewal and differentiation.

机译：损失的辅酶NAD +,这是必需的许多能量依赖性细胞过程成为一个潜在的统一机制与年龄相关的条件。EMBO杂志识别小说之间的联系损耗的NAD +和与年龄有关的损失成人神经干细胞/祖细胞增殖在小鼠的大脑(斯坦,对大脑如何数据有重要的影响函数可能会随着年龄的增长而下降。NAD +损失或Nampt病原生物合成的步骤辅酶,占神经干细胞/祖细胞的损失自我更新和分化。

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来源
《EMBO Journal》 |2014年第12期|1289-1291|共3页
作者
WileyC.; CampisiJ.;
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作者单位

Buck Institute for Research on Aging, Novato CA, United States, Lawrence Berkeley National;

Buck Institute for Research on Aging, Novato CA, United States;

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原文格式 PDF
正文语种英语
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关键词
cerebral function; Coenzymes; Neural Stem CellsCell fateNAD;

机译：脑功能;辅酶;神经干细胞CellsCell;

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NAD+ controls neural stem cell fate in the aging brain

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