首页> 外文期刊>Disease Prevention Daily. >Data on Molecular Science Discussed by Researchers at University Medical Center Hamburg-Eppendorf (Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development)
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Data on Molecular Science Discussed by Researchers at University Medical Center Hamburg-Eppendorf (Effects of Environmental Conditions on Nephron Number: Modeling Maternal Disease and Epigenetic Regulation in Renal Development)

机译:分子科学数据研究人员讨论在汉堡大学医学中心(环境条件对肾单位的影响号码:建模孕产妇疾病和表观遗传调控肾发展)

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2021 MAY 03 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - A new study on molecular science is now available. According to news reporting out of Hamburg, Germany, by NewsRx editors, research stated, "A growing body of evidence suggests that low nephron numbers at birth can increase the risk of chronic kidney disease or hypertension later in life." Financial supporters for this research include FP7 Ideas: European Research Council; H2020 European Research Council; German Research Foundation. Our news correspondents obtained a quote from the research from University Medical Center Hamburg-Eppendorf: "Environmental stressors, such as maternal malnutrition, medication and smoking, can influence renal size at birth. Using metanephric organ cultures to model single-variable environmental conditions, models of maternal disease were evaluated for patterns of developmental impairment. While hyperthermia had limited effects on renal development, fetal iron deficiency was associated with severe impairment of renal growth and nephrogenesis with an all-proximal phenotype. Culturing kidney explants under high glucose conditions led to cellular and transcriptomic changes resembling human diabetic nephropathy Short-term high glucose culture conditions were sufficient for long-term alterations in DNA methylation-associated epigenetic memory. Finally, the role of epigenetic modifiers in renal development was tested using a small compound library."
机译:2021年5月03 (NewsRx)——由一个新闻记者新闻编辑在日常——一种新的疾病预防分子科学研究现在是可用的。根据新闻报道的汉堡德国NewsRx编辑,研究表示,“一个越来越多的证据表明,低出生时肾单位数量会增加的风险慢性肾脏疾病或高血压在后面生活。”包括FP7想法之下:欧洲研究理事会;H2020欧洲研究理事会;的基础。引用从大学医学研究中心汉堡:“环境压力,如孕产妇营养不良,药物和吸烟,会影响肾脏的大小在出生时。模型变量环境条件,孕产妇疾病进行评估的模型模式的发展障碍。高热对肾的影响有限发展,胎儿缺铁有关有严重损伤的肾和增长nephrogenesis all-proximal表型。培养肾外植体在高葡萄糖导致细胞和转录组条件变化类似于人类糖尿病肾病短期高葡萄糖培养条件足够的长期改变DNAmethylation-associated表观遗传的记忆。最后,表观遗传修饰符的作用使用小肾开发测试复合图书馆。”

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