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>Study Findings on Biological Markers Reported by Researchers at Russian Federation (Evaluation of VDR and PAI allelic genes in patients with avascular necrosis of the femoral head)
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Study Findings on Biological Markers Reported by Researchers at Russian Federation (Evaluation of VDR and PAI allelic genes in patients with avascular necrosis of the femoral head)
2021 MAY 03(NewsRx)-By a News Reporter-Staff News Editor at Disease Prevention Daily-Investigators publish new report on biological markers. According to news originating from Moscow, Russia, by NewsRx correspondents, research stated, "To evaluate the informative value of the carrier status for allelic variations that determine the sensitivity of tissues to calcitriol (VDR) and are involved in familial thrombophilia and hypofibrinolysis (PAI-1) as molecular genetic markers of avascular necrosis of the femoral head (AVNFH). A clinical and laboratory study of 300 AVNFH patients, residents of European Russia, was carried out." The news correspondents obtained a quote from the research from Russian Federation: "A comparative analysis of the alleles and genotypes frequency distribution of polymorphisms rsll568820 and rsl544410 of the VDR gene, as well as rsl799889 of the PAI-1 gene in AVNFH patients was performed. AVNFH patients showed a significant increase in the frequencies of the G/G genotype (P = 3.0E-9) and the G allele (P = 0.05) of the rsll568820 VDR polymorphism (P = 2.10E-08) as compared to controls. The frequency of the A/A genotype of the rsl544410 VDR locus in AVNFH individuals was higher than that in controls (P = 0.05). Carriers of the genotype G/G A-3731G (Cdx2) of the VDR gene were shown to have a 2.1-fold increased risk of developing AVNFH; carriers of the G allele appeared to have a 2.3-fold increased risk of AVNFH. The findings showed that the carriership of the 5G allele of the polymorphic locus PAI-1 -675 4G >5G (rsl799889) is detected 1.4 times more often in AVNFH patients than in individuals from the population sample. The risk of developing the pathology is increased 2 times with the carriership of the 5G/5G genotype of this polymorphic locus."
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