New Findings Reported from Jamia Millia Islamia Describe Advances in Leishmaniasis (Cynaroside Inhibits Leishmania Donovani Udp-galactopyranose Mutase and Induces Reactive Oxygen Species To Exert Antileishmanial Response)

首页> 外文期刊>Disease Prevention Daily. >New Findings Reported from Jamia Millia Islamia Describe Advances in Leishmaniasis (Cynaroside Inhibits Leishmania Donovani Udp-galactopyranose Mutase and Induces Reactive Oxygen Species To Exert Antileishmanial Response)

【24h】

New Findings Reported from Jamia Millia Islamia Describe Advances in Leishmaniasis (Cynaroside Inhibits Leishmania Donovani Udp-galactopyranose Mutase and Induces Reactive Oxygen Species To Exert Antileishmanial Response)

机译：新发现报告Jamia Millia Islamia在利什曼病(Cynaroside描述的进步抑制杜氏利什曼虫Udp-galactopyranose变位酶和诱导活性氧发挥Antileishmanial响应)

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

2021 MAY 03 (NewsRx) - By a News Reporter-Staff News Editor at Disease Prevention Daily - Fresh data on Parasitic Diseases and Conditions - Leishmaniasis are presented in a new report. According to news reporting originating from New Delhi, India, by NewsRx correspondents, research stated, "Cynaroside, a flavonoid, has been shown to have antibacterial, antifungal and anticancer activities. Here, we evaluated its antileishmanial properties and its mechanism of action through different in sitico and in vitro assays." Financial support for this research came from Deanship of Scientific Research at Majmaah University, Al Majmaah, Saudi Arabia. Our news editors obtained a quote from the research from Jamia Millia Islamia, "Cynaroside exhibited antileishmanial activity in time- and dose-dependent manner with 50% of inhibitory concentration (IC50) value of 49.49 +/- 3.515 mu M in vitro. It inhibited the growth of parasite significantly at only 20 mu M concentration when used in combination with miltefosine, a standard drug which has very high toxicity It also inhibited the intra-macrophagic parasite significantly at low doses when used in combination with miltefosine. It showed less toxicity than the existing antileishmanial drug, miltefosine at similar doses.

机译：2021年5月03 (NewsRx)——由一个新闻记者在疾病预防每日新闻编辑——新鲜寄生虫病和条件——数据利什曼病提出了一个新的报告。根据新闻报道来自新印度德里NewsRx记者,研究说:“Cynaroside、类黄酮已被证明抗菌,抗真菌和抗癌活动。antileishmanial属性及其机制通过不同的体外sitico和行动化验。”从院长职Majmaah的科学研究大学、阿尔Majmaah沙特阿拉伯。编辑引用的研究获得的Jamia Millia Islamia”Cynaroside展出antileishmanial和活动时间剂量依赖性的方式50%的抑制浓度(IC50) 49.49 + / - 3.515μ的值M体外。明显仅20μM浓度时结合miltefosine,使用标准药物毒性也很高抑制intra-macrophagic寄生虫在低剂量使用时明显结合miltefosine。比现有的antileishmanial毒性药物,miltefosine在类似的剂量。

著录项

来源
《Disease Prevention Daily.》 |2021年第03期|28-29|共2页
作者

展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
luteolin-7-glucoside; miltefosine; newsNew Delhi IndiaUDP-galactopyranose mutaseLeishmaniasisFinancial Supportparasitosisscientific researchLeishmania donovaniDisease Controlled;

机译：luteolin-7-glucoside;miltefosine newsNew德里mutaseLeishmaniasisFinancialSupportparasitosisscientific researchLeishmaniadonovaniDisease控制;

New Findings Reported from Jamia Millia Islamia Describe Advances in Leishmaniasis (Cynaroside Inhibits Leishmania Donovani Udp-galactopyranose Mutase and Induces Reactive Oxygen Species To Exert Antileishmanial Response)

摘要

著录项

相关主题

期刊订阅