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首页> 外文期刊>EMBO Journal >Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans
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Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans

机译：在缺乏一个有机体的传播实用端粒酶通路的秀丽线虫

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摘要

To counteract replication-dependent telomere shortening most eukaryotic cells rely on the telomerase pathway, which is crucial for the maintenance of proliferative potential of germ and stem cell populations of multicellular organisms. Likewise, cancer cells usually engage the telomerase pathway for telomere maintenance to gain immortality. However, in ～10% of human cancers telomeres are maintained through telomerase-independent alternative lengthening of telomeres (ALT) pathways. Here, we describe the generation and characterization of C. elegans survivors in a strain lacking the catalytic subunit of telomerase and the nematode telomere-binding protein CeOB2. These clonal strains, some of which have been propagated for >180 generations, represent the first example of a multicellular organism with canonical telomeres that can survive without a functional telomerase pathway. The animals display the heterogeneous telomere length characteristic for ALT cells, contain single-stranded C-circles, a transcription profile pointing towards an adaptation to chronic stress and are therefore a unique and valuable tool to decipher the ALT mechanism.
机译：为了抵消replication-dependent端粒大多数真核细胞依靠缩短端粒酶途径,这是至关重要的维持细菌的增殖潜力和多细胞的干细胞数量生物。端粒维持端粒酶通路获得永生。癌症的端粒维持telomerase-independent替代延长的端粒(ALT)通路。生成和秀丽隐杆线虫的特性幸存者在一个缺乏催化的压力亚基的端粒酶和线虫CeOB2 telomere-binding蛋白质。菌株,其中一些已经传播了> 180代,代表的第一个例子标准端粒的多细胞生物没有端粒酶功能能够生存途径。ALT细胞端粒长度特征,包含单链C-circles, a指向一个转录概要文件慢性压力,因此适应独特而有价值的工具破译ALT机制。

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