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首页> 外文期刊>EMBO Journal >Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.
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Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.

机译：Nek9 Plk1-activated激酶控制早期通过Nek6/7和中心体分离Eg5。

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摘要

The NIMA-family kinases Nek9/Nercc1, Nek6 and Nek7 form a signalling module required for mitotic spindle assembly. Nek9, the upstream kinase, is activated during prophase at centrosomes although the details of this have remained elusive. We now identify Plk1 as Nek9 direct activator and propose a two-step activation mechanism that involves Nek9 sequential phosphorylation by CDK1 and Plk1. Furthermore, we show that Plk1 controls prophase centrosome separation through the activation of Nek9 and ultimately the phosphorylation of the mitotic kinesin Eg5 at Ser1033, a Nek6/7 site that together with the CDK1 site Thr926 we establish contributes to the accumulation of Eg5 at centrosomes and is necessary for subsequent centrosome separation and timely mitosis. Our results provide a basis to understand signalling downstream of Plk1 and shed light on the role of Eg5, Plk1 and the NIMA-family kinases in the control of centrosome separation and normal mitotic progression.
机译：《NIMA-family kinases Nek9 / Nercc1 Nek6 and Nek7形成一个有丝分裂所需信号模块纺锤体组装。在前期在中心体尽管激活这仍然难以捉摸的细节。识别Plk1 Nek9直接激活提出一种两步激活机制涉及Nek9顺序由CDK1磷酸化和Plk1。前期通过中心体分离激活Nek9并最终的有丝分裂驱动蛋白的磷酸化Eg5Nek6/7网站Ser1033一起CDK1网站Thr926我们建立有助于Eg5中心体和积累随后的中心体分离所必需的和及时的有丝分裂。理解信号下游Plk1的和阐明Eg5的角色,Plk1的NIMA-family激酶在中心体的控制分离和正常有丝分裂进程。

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