Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins.

Lima Fernandes E; Enslen H; Camand EKotelevets LBoularan CAchour LBenmerah AGibson LCBaillie GSPitcher JAChastre EEtienne Manneville SMarullo SScott MG

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Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins.

机译：不同的PTEN功能输出信号控制的动态联系beta-arrestins。

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The tumour suppressor PTEN (phosphatase and tensin deleted on chromosome 10) regulates major cellular functions via lipid phosphatase-dependent and -independent mechanisms. Despite its fundamental pathophysiological importance, how PTEN's cellular activity is regulated has only been partially elucidated. We report that the scaffolding proteins beta-arrestins (beta-arrs) are important regulators of PTEN. Downstream of receptor-activated RhoA/ROCK signalling, beta-arrs activate the lipid phosphatase activity of PTEN to negatively regulate Akt and cell proliferation. In contrast, following wound-induced RhoA activation, beta-arrs inhibit the lipid phosphatase-independent anti-migratory effects of PTEN. beta-arrs can thus differentially control distinct functional outputs of PTEN important for cell proliferation and migration.

机译：肿瘤抑制基因PTEN(磷酸酶和tensin删除10号染色体上)调节主要通过脂质细胞功能phosphatase-dependent和独立机制。病理生理意义,PTEN的方式细胞活动监管才部分阐明。脚手架蛋白beta-arrestins (beta-arrs)PTEN有重要的调控作用。receptor-activated RhoA /摇滚信号,beta-arrs激活脂质磷酸酶活性PTEN的负调节Akt和细胞扩散。wound-induced RhoA激活,beta-arrs抑制的脂质phosphatase-independent anti-migratoryPTEN的影响。不同控制不同的功能对细胞增殖输出PTEN的重要和迁移。

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来源
《EMBO Journal》 |2011年第13期|2557-2568|共12页
作者
Lima Fernandes E; Enslen H; Camand EKotelevets LBoularan CAchour LBenmerah AGibson LCBaillie GSPitcher JAChastre EEtienne Manneville SMarullo SScott MG;
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作者单位

INSERM, U1016, Institut Cochin, Paris, France.;

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原文格式 PDF
正文语种英语
中图分类分子生物学;分子生物学;
关键词
Output; Tensins; Casein PhosphataseDistinctPTEN PhosphohydrolaseChromosomes, Human, Pair 10Cell Proliferationbeta-Arrestins;

机译：输出;Tensins PhosphataseDistinctPTEN酪蛋白PhosphohydrolaseChromosomes,人类,对10个细胞;

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Distinct functional outputs of PTEN signalling are controlled by dynamic association with beta-arrestins.

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