Understanding cargo specificity in intraflagellar transport.

Parker DS; Katsanis N

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Understanding cargo specificity in intraflagellar transport.

机译：了解货物在intraflagellar特异性交通工具。

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Cilia biogenesis and maintenance depends on intraflagel-lar transport (IFT) that at the same time mediates shuttling of cell-type-specific cargo. Mechanistic understanding of how the general IFT transport machinery links to the movement of specific ciliary cargo remains sparse. In this issue of The EMBO Journal, Zhao and Malicki (2011) show that two components of the IFT machinery (Fleer and IFT88) interact with axoneme and basal body localized factors (B9d2 and Inversin) to regulate transport of specific ciliary cargo.

机译：纤毛生物起源和维护取决于在同一intraflagel-lar传输(IFT)细胞类型特异的。时间调节的穿梭货物。一般IFT运输机械的链接特定的纤毛运动货物仍然存在稀疏。和中场(2011)表明,两个组成部分IFT机械(讥笑和IFT88)相互作用基因丝和基体局部因素(B9d2和Inversin)调节传输特定的纤毛的货物。

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来源
《EMBO Journal》 |2011年第13期|2518-2519|共2页
作者
Parker DS; Katsanis N;
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作者单位

Department of Cell Biology and Pediatrics, Center for Human Disease Modeling, Duke University, Durham, NC, USA.;

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原文格式 PDF
正文语种英语
中图分类分子生物学;分子生物学;
关键词
transport machinery; Axoneme; IFT88 geneTWO-COMPONENTcargo;

机译：运输机械;基因丝;IFT88geneTWO-COMPONENTcargo;

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Understanding cargo specificity in intraflagellar transport.

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