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首页> 外文期刊>EMBO Journal >Re-dicing the pancreatic beta-cell: do microRNAs define cellular identity?
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Re-dicing the pancreatic beta-cell: do microRNAs define cellular identity?

机译：Re-dicing胰腺β细胞:做小分子核糖核酸定义手机身份?

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摘要

Understanding the mechanisms which contribute to successful growth and function of the pancreatic p-cell is essential to our ability to combat the global epidemic of diabetes. To date, there is limited in vivo data addressing the role of microRNAs or components of the RNAi machinery in the pancreatic p-cell. In this issue of The EMBO Journal, Melkman-Zehavi et al provide further evidence of how small RNAs contribute to the normal growth and function of this cell type, characterizing the metabolic consequences of Dicer depletion. Their study highlights the role of miR-24, miR-26, and miR-148 in promoting insulin mRNA levels and begins to suggest potential for many other microRNAs to contribute to an already complex story.
机译：这有助于理解机制成功的增长和胰腺的功能p-cell对我们打击的能力至关重要全球流行的糖尿病。体内数据处理的作用有限小分子核糖核酸或组件的RNAi机械胰腺p-cell。杂志,Melkman-Zehavi等进一步提供的小分子rna为证据正常生长和功能的细胞类型,代谢的影响特征帽子损耗。miR-24 miR-26,并在促进mir - 148胰岛素mRNA水平并开始显示许多其他小分子核糖核酸贡献的潜力本已复杂的故事。

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