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首页> 外文期刊>Advanced Biosystems >Human Skin Equivalents Demonstrate Need for Neuro-lmmuno-Cutaneous System
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Human Skin Equivalents Demonstrate Need for Neuro-lmmuno-Cutaneous System

机译：人类皮肤等价物演示需要Neuro-lmmuno-Cutaneous系统

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摘要

A variety of human skin equivalents (HSEs) has been designed for clinical use or for exploratory skin research. In vitro HSE models have been used to target relationships between the skin and nervous or immune systems but have not yet considered the neuro-immuno-cutaneous (NIC) system. In this study, HSEs are described, with and without neural and immune components, to discern these types of effects. These systems are composed of only primary human cells and contain an epidermis, dermis, hypodermis (with immune cells), and human induced neural stem cells for the neuronal component. RNA sequencing is utilized to confirm differences between sample groups and to identify unique or important genes with respect to sample type. Only samples with both neural and immune components result in the upregulation of genes in all the key biological pathways explored. The analysis of protein secretion confirms that this group has measurable functions related to all key cell types. Overall, this novel skin tissue system confirms that designing HSEs that include the NIC system results in a tissue model that reflects key functions. These systems could be used to identify selected targets ofinterest in skin research related to healthy or diseased states.
机译：各种各样的人类皮肤等价物(hse)为临床使用或探索性的设计皮肤的研究。针对皮肤和之间的关系紧张或免疫系统但尚未认为neuro-immuno-cutaneous (NIC)系统。和没有神经和免疫组件辨别这些类型的影响。只有主人体细胞和包含组成一个表皮,真皮,真皮(免疫细胞),和人类诱导神经干细胞神经元的组件。用于确定样本之间的差异组织和确定独特的或重要的基因关于样品类型。导致神经和免疫组件upregulation基因在所有生物的关键途径探索。分泌确认这组可衡量的功能相关的所有关键的细胞类型。这部小说皮肤组织系统确认设计商品,包括网卡系统结果在组织模型,反映了关键功能。确定所选目标ofinterest在皮肤上研究相关的健康或患病的状态。

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