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How long can bacteriophage λ change its mind?

机译：多久可以噬菌体λ改变主意吗?

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摘要

A key event in the lifecycle of a temperate bacteriophage is the choice between lysis and lysogeny upon infection of a susceptible host cell. In a recent paper, we showed that a prolonged period exists after the decision to lysogenize, during which bacteriophage λ can abandon the initial decision, and instead develop lytically, as a response to the accumulation of the late lytic regulatory protein Q. Here, we present evidence that expression of Q does not induce replication of λ DNA, suggesting that the DNA to be packaged into the resulting phage progeny was already present at the time of the initial decision to lysogenize. We summarize our findings in a working model of the key determinants of the duration of the post-decision period during whichit is possible for the infected cell to switch from the lysogeny decision to successful lytic development.
机译：温带的生命周期中的关键事件噬菌体裂解和之间的选择溶原性感染的易感宿主细胞。长期存在的决定之后lysogenize,噬菌体λ放弃最初的决定,而不是发展lytically作为回应的积累后期蛋白质溶解性监管问:这里,我们目前的证据表明,表达Q不引入λDNA的复制,这表明DNA被打包到噬菌体后代的时候就已经存在lysogenize最初的决定。发现一个工作模型的关键决定因素的政策例会后的持续时间期间当中的受感染的细胞从溶原性开关决定成功的溶解性发展。

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