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Phage fitness may help predict phage therapy efficacy

机译：噬菌体健身可以帮助预测噬菌体疗法功效

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摘要

We isolated 6 phages from 2 environmental water sources and assessed their ability to treat Pseudomonas aeruginosa infection of Drosophila melanogaster. We found all 6 phages were able to significantly increase mean survival time (MST) of infected D.melanogaster. Although phage traits, such as adsorption rate, burst size, and lysis time, varied significantly among these phages, none of the traits correlated significantly with MST. Phage growth rate determined in vitro, however, was found to be significantly correlated with MST. Overall, our study shows that infected D. melanogaster can be used as a model system to test the therapeutic efficacy of phages. In addition, a more comprehensive characteristic, like the in vitro growth rate, seems to be abetter indicator in predicting therapeutic success than constituent traits like the adsorption rate, burst size, or lysis time.
机译：我们从2环境水分离出6噬菌体源和评估治疗的能力铜绿假单胞菌感染的果蝇腹。显著提高平均生存时间(MST)受感染的D.melanogaster。特征,如吸附率、释放量溶解时间,其中之间存在着显著的差异噬菌体,没有特征相关的MST显著。然而,确定体外被发现MST显著相关。研究表明,感染d .腹作为一个模型系统来测试治疗噬菌体的效果。全面的特点,在体外增长率,似乎是更好的指标比组成预测治疗成功特征的吸附率、释放量或溶解时间。

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