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首页> 外文期刊>Bacteriophage >Applying the ResFinder and VirulenceFinder web-services for easy identification of acquired antibiotic resistance and E. coli virulence genes in bacteriophage and prophage nucleotidesequences
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Applying the ResFinder and VirulenceFinder web-services for easy identification of acquired antibiotic resistance and E. coli virulence genes in bacteriophage and prophage nucleotidesequences

机译：应用ResFinder VirulenceFinderweb服务,以方便识别抗生素耐药性和大肠杆菌毒力基因在噬菌体和前噬菌体nucleotidesequences

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摘要

Extensive research is currently being conducted on the use of bacteriophages for applications in human medicine, agriculture and food manufacturing. However, phages are important vehicles of horisontal gene transfer and play a significant role in bacterial evolution. As a result, concern has been raised that this increased use and dissemination of phages could result in spread of deleterious genes, e.g., antibiotic resistance and virulence genes.Meanwhile, in the wake of the genomic era, several tools have been developed for characterization of bacterial genomes. Here we describe how two of these tools, ResFinder and VirulenceFinder, can be used to identify acquired antibiotic resistance and virulence genes in phage genomes of interest. The general applicability of the tools is demonstrated on data sets of 1,642 phage genomes and 1,442 predicted prophages.
机译：广泛的研究目前正在进行噬菌体的使用应用程序人类医学、农业和食物制造业。车辆horisontal基因转移和发挥在细菌进化的重要作用。因此,这已被提出的问题增加使用和传播噬菌体导致有害基因的传播,例如,抗生素耐药性和毒性基因。几个工具开发细菌基因组的特征。描述两个工具,ResFinder和VirulenceFinder,可以用来识别抗生素耐药性和毒力基因噬菌体基因组的兴趣。适用性的工具了噬菌体基因组1642和1442的数据集预测噬菌体原。

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