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首页> 外文期刊>EMBO Journal >A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C-elegans
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A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C-elegans

机译：与神经胶质度/钠通道功能通道DEG-1调解具体感觉函数C-elegans

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Mammalian neuronal DEG/ENaC channels known as ASICs (acid-sensing ion channels) mediate sensory perception and memory formation. ASICS are closed at rest and are gated by protons. Members of the DEG/ENaC family expressed in epithelial tissues are called ENaCs and mediate Na+ transport across epithelia. ENaCs exhibit constitutive activity and strict Na+ selectivity. We report here the analysis of the first DEG/ENaC in Caenorhabditis elegans with functional features of ENaCs that is involved in sensory perception. ACD-1 (acid-sensitive channel, degenerin-like) is constitutively open and impermeable to Ca2+, yet it is required with neuronal DEG/ENaC channel DEG-1 for acid avoidance and chemotaxis to the amino acid lysine. Surprisingly, we document that ACD-1 is required in glia rather than neurons to orchestrate sensory perception. We also report that ACD-1 is inhibited by extracellular and intracellular acidification and, based on the analysis of an acid-hypersensitive ACD-1 mutant, we propose a mechanism of action of ACD-1 in sensory responses based on its sensitivity to protons. Our findings suggest that channels with ACD-1 features may be expressed in mammalian glia and have important functions in controlling neuronal function.
机译：哺乳动物神经度/钠通道被称为酸感性离子通道(asic)调解的感觉知觉和记忆形成。在休息和封闭的质子。度/博家人表达上皮组织被称为博和调解Na +运输吗上皮细胞。和严格的Na +选择性。分析的第一个度/钠秀丽线虫与钠的功能特性参与感官知觉。(degenerin-like acid-sensitive通道)既定的开放和不透水Ca2 +它与神经度/钠通道是必需的DEG-1避免酸和趋化性氨基酸赖氨酸。ACD-1神经元在神经胶质是必需的,而不是安排感官知觉。抑制细胞外和ACD-1细胞内酸化,基于分析一个acid-hypersensitive ACD-1突变体,我们提出一个ACD-1的作用机制基于其灵敏度的感官反应质子。ACD-1特性表现在哺乳动物神经胶质重要的控制功能神经元的功能。

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