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Phage therapy: Should bacterial resistance to phages be a concern, even in the long run?

机译：噬菌体疗法:细菌耐药性噬菌体是一种担忧,甚至从长远来看?

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Bacteriophage therapy, the use of viruses that infect bacteria as antimicrobials, has been championed as a promising alternative to conventional antibiotics. Although in the laboratory bacterial resistance against phages arises rapidly, resistance sofar has been an only minor problem for the effectiveness of phage therapy. Resistance to antibiotics, however, has become a major issue after decades of extensive use. Should we expect similar problems after long-term use of phages as antimicrobials? Like antibiotics, phages are often noted to be drivers of bacterial evolution. Should we expect phage-treated pathogens to develop a general resistance to phages over time, a resistance against which only, for example, hypothetically co-evolved phages mightbe infective? Here we argue that the global infection patterns of phages suggest that this is not necessarily a concern as environmental phages often can infect bacteria with which those phages lack any recent co-evolutionary history.
机译：噬菌体疗法,使用病毒抗菌素,感染细菌倡导作为一个有前途的替代传统的抗生素。实验室细菌抵抗噬菌体迅速出现,抵抗迄今为止,一直是唯一的小问题对噬菌体的有效性治疗。经过几十年的广泛的成为一个主要的问题使用。噬菌体的长期使用抗菌素?抗生素、噬菌体往往指出司机进化的细菌。phage-treated病原体发展一般抗噬菌体随着时间的推移,一个阻力对,例如,假设噬菌体的生活感染密切相关?认为,全球感染模式噬菌体认为这不一定关注环境噬菌体往往可以感染最近这些噬菌体缺乏任何细菌进化论的历史。

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