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首页> 外文期刊>EMBO Journal >Nuclear export modulates the cytoplasmic Sir2 homologue Hst2
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Nuclear export modulates the cytoplasmic Sir2 homologue Hst2

机译：核出口调节细胞质Sir2同源Hst2

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摘要

Modulating transcription factors is crucial to executing sophisticated gene expression programs. The silent information regulator 2 (Sir2) family of NAD-dependent protein deacetylases influences transcription by targeting proteins such as histones, p53 and forkhead-box family transcription factors. Although apparently cytoplasmic, both mammalian SIRT2 and its yeast orthologue Hst2 have been implicated in transcriptional regulation. Here, we show that Hst2 moves between the nucleus and cytoplasm, but is largely cytoplasmic owing to efficient nuclear export. This nuclear exclusion is mediated by the exportin chromosomal region maintenance 1 (Crm1) and a putative leucine-rich nuclear export sequence in Hst2, which overlaps a unique autoregulatory helix. Disruption of Hst2 export shows that nuclear exclusion inhibits the activity of Hst2 as a transcriptional repressor. Our identification of putative nuclear export sequences in numerous vertebrate SIRT2 proteins shows that active nuclear export can be a conserved mechanism for regulating Sir2 homologues.
机译：调节转录因子是至关重要的执行复杂的基因表达程序。沉默的信息监管机构2 (Sir2)的家庭NAD-dependent蛋白去乙酰酶抑制剂的影响针对蛋白质如转录组蛋白、p53和forkhead-box家庭转录因子。细胞质,哺乳动物SIRT2和酵母orthologue Hst2已经涉及转录调控。Hst2细胞核和细胞质之间移动,但是主要是胞质由于有效核吗出口。间染色体区域维护1 (Crm1)和一个假定的富亮氨酸核出口Hst2序列,重叠一个独一无二的自动调整的螺旋。表明核排除抑制Hst2作为转录抑制因子的活性。我们假定的核出口的识别在很多脊椎动物SIRT2蛋白质序列核出口可以显示活跃调节Sir2守恒的机制同行的人。

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