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首页> 外文期刊>EMBO Journal >Two internal ribosome entry sites mediate the translation of p53 isoforms
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Two internal ribosome entry sites mediate the translation of p53 isoforms

机译：两个内部核糖体进入位点进行调解翻译p53亚型

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摘要

The p53 tumour suppressor protein has a crucial role in cell-cycle arrest and apoptosis. Previous reports show that the p53 messenger RNA is translated to produce an amino-terminal-deleted isoform (Delta N-p53) from an internal initiation codon, which acts as a dominant-negative inhibitor of full-length p53. Here, we show that two internal ribosome entry sites (IRESs) mediate the translation of both full-length and Delta N-p53 isoforms. The IRES directing the translation of full-length p53 is in the 5'-untranslated region of the mRNA, whereas the IRES mediating the translation of Delta N-p53 extends into the protein-coding region. The two IRESs show distinct cell-cycle phase-dependent activity, with the IRES for full-length p53 being active at the G2-M transition and the IRES for Delta N-p53 showing highest activity at the G1-S transition. These results indicate a novel translational control of p53 gene expression and activity.
机译：肿瘤抑制基因p53蛋白有一个至关重要的在细胞循环逮捕和细胞凋亡中的作用。报告显示,p53信使RNA翻译产生amino-terminal-deleted同种型(δN-p53)从内部开始密码子,它充当一个显性负全身p53的抑制剂。两个内部核糖体进入位点(ires)调解两个完整的翻译和三角洲N-p53亚型。全身p53在翻译5 '非翻译区信使rna,而IRES调停δN-p53的翻译延伸到蛋白质编码区域。ires显示不同的细胞循环phase-dependent活动,全身p53的忿怒活跃在G2-M过渡和忿怒三角洲N-p53 G1-S显示最高的活动过渡。平移p53基因表达和控制活动。

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