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首页> 外文期刊>EMBO Journal >Ca2+ shuttling between endoplasmic reticulum and mitochondria underlying Ca2+ oscillations
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Ca2+ shuttling between endoplasmic reticulum and mitochondria underlying Ca2+ oscillations

机译：Ca2 +往返于内质网线粒体底层Ca2 +振荡

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摘要

Although many cell functions are regulated by Ca2+ oscillations induced by a cyclic release of Ca2+ from intracellular Ca2+ stores, the pacemaker mechanism of C2+ oscillations remains to be explained. Using green fluorescent protein-based Ca2+ indicators that are targeted to intracellular Ca2+ stores, the endoplasmic reticulum (ER) and mitochondria, we found that Ca2+ shuttles between the ER and mitochondria in phase with Ca2+ oscillations. Following agonist stimulation, Ca2+ release from the ER generated the first Ca2+ oscillation and loaded mitochondria with Ca2+. Before the second Ca2+ oscillation, Ca2+ release from the mitochondria by means of the Na+/Ca2+ exchanger caused a gradual increase in cytoplasmic Ca2+ concentration, inducing a regenerative ER Ca2+ release, which generated the peak of Ca2+ oscillation and partially reloaded the mitochondria. This sequence of events was repeated until mitochondrial Ca2+ was depleted. Thus, Ca2+ shuttling between the ER and mitochondria may have a pacemaker role in the generation of Ca2+ oscillations.
机译：尽管许多细胞功能受Ca2 +振动引起的循环Ca2 +的释放从细胞内钙离子商店,起搏器C2 +振荡机理还有待解释说。针对Ca2 +指标细胞内钙离子商店,内质的网(ER)和线粒体,我们发现Ca2 + ER与线粒体之间的航天飞机与钙离子振荡阶段。刺激,Ca2 +释放产生的ER第一个Ca2 +振荡和加载线粒体Ca2 +。振荡,Ca2 +从线粒体释放通过Na + / Ca2 +换热器造成在胞质钙离子逐渐增加浓度、诱导再生ER Ca2 +释放,产生Ca2 +的巅峰振荡和部分重新加载线粒体。重复,直到线粒体钙离子耗尽。因此,ER和Ca2 +之间穿梭线粒体可能起搏器作用代的Ca2 +振荡。

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